ASIC3 - acid sensing ion channel subunit 3 Gene

Also Known as ACCN3; TNaC1; DRASIC; SLNAC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9311

About ASIC3

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,048,292-151,052,756 (from NCBI)

This gene has 9 transcripts (splice variants), 117 orthologues and 8 paralogues. Broad expression in testis (RPKM 3.0), brain (RPKM 2.0) and 20 other tissues.

Summary

This gene encodes a member of the degenerin/epithelial Sodium Channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

ASIC3 Products (3)

mRNA Protein Name
NM_004769.4 NP_004760.1 acid-sensing ion channel 3 isoform a
NM_020321.3 NP_064717.1 acid-sensing ion channel 3 isoform b
NM_020322.3 NP_064718.1 acid-sensing ion channel 3 isoform c

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in sensory perception of sour taste IMP
IMP: Inferred from mutant phenotype
19812697 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASIC3 Protein Structure

ASC

ASC: Amiloride-sensitive sodium channel (20 - 460)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 531 a.a.
Protein Preferred Names Protein Names

acid-sensing ion channel 3

  • acid sensing (proton gated) ion channel 3

Related Diseases

Diseases Alias
Acute Salpingo-Oophoritis

  • Acute Salpingitis And Oophoritis
Frozen Shoulder

  • Adhesive Capsulitis Of Shoulder

  • Bursitis

  • Adhesions-Capsulitis,Shoulder

  • Pericapsulitis Of Shoulder

  • Duplay Bursitis

  • Adhesive Shoulder Peritendinitis

  • Subscapular Adhesion

  • Shoulder Adhesion

  • Adhesive Enthesopathy Of Shoulder Region

  • Adhesive Peritendinitis

  • Adhesive Shoulder Tenosynovitis

  • Duplay Periarthritis

  • Adhesive Shoulder Tendinitis
Femoral Cancer

  • Femoral Neoplasms

  • Cancer Of The Femur

  • Femoral Neoplasm

  • Neoplasm Of Femur
Myofascial Pain Syndrome

  • Myofascial Pain Syndromes

  • Myofascial Pain Dysfunction Syndrome

  • Fibromyalgia
Miliaria Rubra

  • Miliaria

  • Prickly Heat

  • Miliaria Crystallina
Complex Regional Pain Syndrome

  • Complex Regional Pain Syndromes

  • Reflex Sympathetic Dystrophy

  • Crps
Somatoform Disorder

  • Physiological Malfunction Arising From Mental Factor

  • Psychosomatic Disorder

  • Psychophysiologic Disorders
Paine Syndrome

  • Pain Disorder

  • Pain

  • Microcephaly With Spastic Diplegia

  • Pain Syndrome
Paroxysmal Extreme Pain Disorder

  • PEPD

  • Familial Rectal Pain

  • Pexpd

  • Submandibular, Ocular, And Rectal Pain With Flushing

  • Pain, Submandibular, Ocular, And Rectal, With Flushing

  • Rectal Pain, Familial

  • Submandibular, Ocular And Rectal Pain With Flushing

  • Familial Rectal Syndrome

  • Frp

  • Pain Disorder, Paroxysmal, Extreme
Chronic Fatigue Syndrome

  • Myalgic Encephalomyelitis

  • Postviral Fatigue Syndrome

  • Cfs

  • Myalgic Encephalitis

  • Encephalomyelitis, Myalgic

  • Chronic Fatigue

  • Fatigue Syndrome, Chronic

  • Benign Myalgic Encephalomyelitis

  • Akureyri

  • Akureyri Disease

  • Cfs - [Chronic Fatigue Syndrome]

  • Epidemic Neuromyasthenia

  • Myalgic Encephalomyelitis Syndrome

  • Me - [Myalgic Encephalomyelitis]

  • Pvfs - [Postviral Fatigue Syndrome]

  • Neuromyasthenia

  • Iceland Disease

  • Icelandic Disease
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0814 DAPI dihydrochloride Inhibitor 99.90% Unkown
HY-D1738 DAPI dilactate 99.0% Unkown
HY-D2868 DAPI Inhibitor 98.01% Unkown
HY-107757 GMQ hydrochloride Activator 99.86% Unkown
HY-122135 A-317567 Inhibitor 99.34% Unkown
HY-131879 NS383 99.83% Unkown
HY-DY1081 DAPI dihydrochloride (solution) Inhibitor / Unkown
HY-P1346A APETx2 TFA Inhibitor 99.57% Unkown
HY-P1441A Mambalgin 1 TFA Inhibitor 95.72% Unkown
HY-100939 4-Chlorophenylguanidine hydrochloride Agonist 99.07% Unkown
HY-P1346 APETx2 Inhibitor / Unkown
HY-155017 6-Iodoamiloride Inhibitor / Unkown
HY-P1249 Neuropeptide SF(mouse,rat) Agonist / Unkown
HY-P1249A Neuropeptide SF(mouse,rat) TFA Agonist / Unkown
HY-RS01091 ASIC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17225 Asic3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23678 Asic3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ASIC3 VGNC VGNC:38179
Bos taurus ASIC3 VGNC VGNC:26212
Felis catus ASIC3 VGNC VGNC:59972
Macaca mulatta ASIC3 VGNC VGNC:80797
Rattus norvegicus ASIC3 RGD RGD:708578
Mus musculus ASIC3 MGD MGI:2159339
Others ASIC3 NCBI