Loxl2 - lysyl oxidase-like 2 Gene

Also Known as 1110004B06Rik; 4930526G11Rik; 9430067E15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 94352

Summary

Predicted to enable metal ion binding activity; oligosaccharide binding activity; and protein-lysine 6-oxidase activity. Involved in negative regulation of stem cell population maintenance; positive regulation of chondrocyte differentiation; and response to hypoxia. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in brain. Orthologous to human LOXL2 (Lysyl Oxidase like 2). [provided by Alliance of Genome Resources, Apr 2022]

Loxl2 Products (1)

mRNA Protein Name
NM_033325.2 NP_201582.2 lysyl oxidase homolog 2 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of stem cell population maintenance IDA
IDA: Inferred from direct assay
25959397 MGI
involved in positive regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
21071451 MGI
involved in response to hypoxia IDA
IDA: Inferred from direct assay
21835952 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysyl oxidase homolog 2

  • lysyl oxidase-like protein 2

Recombinant Loxl2 Proteins

Cat. No. Product Name Accession Purity
HY-P74769 LOXL2 Protein, Mouse (HEK293, His) P58022-1 (Q26-Q776) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-127009 Levoleucovorin 98.53% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-107422 Lenumlostat 99.52% Phase 2
HY-138625B PXS-5505 Inhibitor / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99047 Simtuzumab Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138625 PXS-5505 free base Inhibitor 99.97% Unkown
HY-101771A (2-Chloropyridin-4-yl)methanamine hydrochloride 99.70% Unkown
HY-138625A PXS-5505 anhydrous Inhibitor 99.90% Unkown
HY-114286A PXS-5153A monohydrochloride Inhibitor 99.59% Unkown
HY-170538 SNT-5382 Inhibitor 99.96% Unkown
HY-151499A PXS-6302 hydrochloride Inhibitor 99.57% Unkown
HY-N0554 Escin IA Inhibitor 99.59% Unkown
HY-151498A PXS-4787 hydrochloride Inhibitor 99.71% Unkown
HY-171955 LXG6403 99.85% Unkown
HY-170573A LOXL2-IN-1 tosylate Inhibitor 99.90% Unkown
HY-130242 PXS-5120A 98.12% Unkown
HY-114286 PXS-5153A Inhibitor / Unkown
HY-151498 PXS-4787 Inhibitor / Unkown
HY-151499 PXS-6302 Inhibitor / Unkown
HY-RS16627 Loxl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107422A Lenumlostat hydrochloride / Unkown
HY-170573 LOXL2-IN-1 Inhibitor / Unkown
HY-180581 LOXL2/sGC modulator-1 / Unkown
HY-180585 LOXL2/sGC modulator-2 / Unkown
HY-183644 LNO 9 Inhibitor / Unkown
HY-RS07742 LOXL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21632 Loxl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23062 Loxl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W036566 2-Phenylcyclopropanamine Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Loxl2 NCBI NCBI:4017