LOXL2 - lysyl oxidase like 2 Gene

Also Known as LOR; LOR2; WS9-14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4017

About LOXL2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,296,897-23,404,120 (from NCBI)

This gene has 15 transcripts (splice variants), 289 orthologues and 15 paralogues. Broad expression in placenta (RPKM 21.2), fat (RPKM 16.1) and 20 other tissues.

Summary

This gene encodes a member of the Lysyl Oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

LOXL2 Products (1)

mRNA	Protein	Name
NM_002318.3	NP_002309.1	lysyl oxidase homolog 2 precursor

LOXL2 Protein Structure

SRCR

Lysyl_oxidase

0
200
400
600
774 a.a.

Protein Preferred Names	Protein Names
lysyl oxidase homolog 2	lysyl oxidase related 2

LOXL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	LOXL2	Q9Y4K0	FN1	Homo sapiens	P02751	SPR	31759052
Intra	LOXL2	Q9Y4K0	FN1	Homo sapiens	P02751	PLA	31759052
Intra	LOXL2	Q9Y4K0	VIM	Homo sapiens	P08670	Anti Tag CoIP	31911079
Intra	LOXL2	Q9Y4K0	VIM	Homo sapiens	P08670	Anti Bait CoIP	31911079
Intra	LOXL2	Q9Y4K0	VIM	Homo sapiens	P08670	PLA	31911079
Intra	LOXL2	Q9Y4K0	MARCKSL1	Homo sapiens	P49006	Anti Tag CoIP	24863880
Intra	LOXL2	Q9Y4K0	MARCKSL1	Homo sapiens	P49006	Y2H	24863880
Intra	LOXL2	Q9Y4K0	MARCKSL1	Homo sapiens	P49006	Anti Bait CoIP	24863880
Intra	LOXL2	Q9Y4K0	ELN	Homo sapiens	P15502-2	SPR	30676771
Intra	LOXL2	Q9Y4K0	ELN	Homo sapiens	P15502-2	Deamination	30676771

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LOXL2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P74770	LOXL2 Protein, Human (HEK293, His)	Q9Y4K0 (Q26-Q774)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74771	LOXL2 Protein, Human (CHO, His)	Q9Y4K0 (Q26-Q774)	≥ 95%, as determined by reducing SDS-PAGE.

LOXL2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P810735	LOXL2 Antibody (YA9979)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P810756	LOXL2 Antibody (YA9999)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P81861	LOXL2 Antibody (YA1606)	WB, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hyperostosis Cranialis Interna	HCIN Hyperostosis Cranalis Interna
Cutis Laxa	Generalized Elastolysis Loose Skin Dermatolysis Dermatomegaly Cutis Laxa Syndrome
Distal Muscular Dystrophy With Anterior Tibial Onset	Dmat
Pelvic Inflammatory Disease	Pid
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-127009	Levoleucovorin		98.53%	Yes

Clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-107422	Lenumlostat		99.52%	Phase 2
HY-138625B	PXS-5505	Inhibitor	/	Phase 2

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P99047	Simtuzumab	Inhibitor	≥99.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (24)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-138625	PXS-5505 free base	Inhibitor	99.97%	Unkown
HY-101771A	(2-Chloropyridin-4-yl)methanamine hydrochloride		99.70%	Unkown
HY-138625A	PXS-5505 anhydrous	Inhibitor	99.90%	Unkown
HY-114286A	PXS-5153A monohydrochloride	Inhibitor	99.59%	Unkown
HY-170538	SNT-5382	Inhibitor	99.96%	Unkown
HY-151499A	PXS-6302 hydrochloride	Inhibitor	99.57%	Unkown
HY-N0554	Escin IA	Inhibitor	99.59%	Unkown
HY-151498A	PXS-4787 hydrochloride	Inhibitor	99.71%	Unkown
HY-171955	LXG6403		99.85%	Unkown
HY-170573A	LOXL2-IN-1 tosylate	Inhibitor	99.90%	Unkown
HY-130242	PXS-5120A		98.12%	Unkown
HY-114286	PXS-5153A	Inhibitor	/	Unkown
HY-151498	PXS-4787	Inhibitor	/	Unkown
HY-151499	PXS-6302	Inhibitor	/	Unkown
HY-RS16627	Loxl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-107422A	Lenumlostat hydrochloride		/	Unkown
HY-170573	LOXL2-IN-1	Inhibitor	/	Unkown
HY-180581	LOXL2/sGC modulator-1		/	Unkown
HY-180585	LOXL2/sGC modulator-2		/	Unkown
HY-183644	LNO 9	Inhibitor	/	Unkown
HY-RS07742	LOXL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21632	Loxl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23062	Loxl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W036566	2-Phenylcyclopropanamine	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LOXL2	MGD	MGI:2137913
Bos taurus	LOXL2	VGNC	VGNC:30953
Rattus norvegicus	LOXL2	RGD	RGD:1308435
Canis familiaris	LOXL2	VGNC	VGNC:42739
Felis catus	LOXL2	VGNC	VGNC:68080
Others	LOXL2	NCBI