CD58 - CD58 molecule Gene

Also Known as ag3; LFA3; LFA-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 965

About CD58

Cytogenetic location: 1p13.1 Genomic coordinates (GRCh38): 1:116,514,534-116,571,026 (from NCBI)

This gene has 5 transcripts (splice variants) and 77 orthologues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

CD58 Products (2)

mRNA	Protein	Name
NM_001144822.2	NP_001138294.1	lymphocyte function-associated antigen 3 isoform 2
NM_001779.3	NP_001770.1	lymphocyte function-associated antigen 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7544493	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	17344209	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	19109405	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	19109405	GOA
involved in heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	15345303	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	19109405	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	15345303	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
lymphocyte function-associated antigen 3	CD58 antigen, (lymphocyte function-associated antigen 3)

Recombinant CD58 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72720	CD58 Protein, Human (HEK293, His)	AAH05930 (F29-R215)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75392	CD58 Protein, Human (HEK293, Fc)	Q9BRW0 (F29-R215)	≥ 95%, as determined by reducing SDS-PAGE.

CD58 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81560	CD58 Antibody (YA1305)	WB, FC	Human

Related Diseases

Diseases	Alias
Oral Lichen Planus	Oral Lichenoid Lesions Lichen Planus Oral Lichen Planus, Oral
Paroxysmal Nocturnal Hemoglobinuria	Marchiafava-Micheli Disease Pnh Hemoglobinuria, Paroxysmal Marchiafava-Micheli Syndrome Paroxysmal Hemoglobinuria Nocturnal Nocturnal Haemoglobinuria Nocturnal Paroxysmal Haematuria Nocturnal Paroxysmal Haemoglobinaemia
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Mcd Diffuse Large B-Cell Lymphoma	Mcd Dlbcl Doid:0081066
Hemoglobinuria
Congenital Dyserythropoietic Anemia	Congenital Dyshaematopoietic Anaemia Dyserythropoietic Anemia, Congenital Cda Anemia, Dyserythropoietic, Congenital Anemia Dyserythropoietic Congenital Cda - [Congenital Dyserythropoietic Anaemia] Dyserythropoietic Dyshaematopoietic Congenital Anaemia Dyshaematopoietic Anaemia Dyserythropoietic Anaemia
Psoriasis
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
St2 Diffuse Large B-Cell Lymphoma	St2 Dlbcl Doid:0081068
Alcoholic Liver Cirrhosis	Alcoholic Cirrhosis Portal Cirrhosis Alcoholic Cirrhosis Of Liver Liver Cirrhosis, Alcoholic Laennec'S Cirrhosis Laennec'S Cirrhosis, Alcoholic Alcohol Cirrhosis Alcoholic Laennec Cirrhosis Alcoholic Cirrhosis Nos Etoh Cirrhosis Alcohol Hepatic Cirrhosis Alcohol Liver Cirrhosis Laennec Cirrhosis
Diffuse Large B-Cell Lymphoma Activated B-Cell Type	Dlbcl Abc Type
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit	Hgbl-Dh/Th High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02256	CD58 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown