EIF5B - eukaryotic translation initiation factor 5B Gene

Also Known as IF2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9669

About EIF5B

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:99,337,389-99,401,326 (from NCBI)

This gene has 5 transcripts (splice variants), 108 orthologues and 18 paralogues. Ubiquitous expression in heart (RPKM 26.2), testis (RPKM 23.3) and 25 other tissues.

Summary

Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with Other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]

EIF5B Products (1)

mRNA Protein Name
NM_015904.4 NP_056988.3 eukaryotic translation initiation factor 5B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
10659855 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
10659855 GOA
enables GTPase activity IMP
IMP: Inferred from mutant phenotype
35732735 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12569173 GOA
enables tRNA binding IDA
IDA: Inferred from direct assay
35732735 GOA
enables translation initiation factor activity IDA
IDA: Inferred from direct assay
10432305 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of translational initiation IDA
IDA: Inferred from direct assay
10432305 GOA
involved in ribosome assembly IDA
IDA: Inferred from direct assay
10659855 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12426392 GOA
NOT located in nucleus IDA
IDA: Inferred from direct assay
12426392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF5B Protein Structure

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (632 - 842)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (870 - 944)

IF-2

IF-2: Translation-initiation factor 2 (965 - 1070)

GTP_EFTU_D4

GTP_EFTU_D4: Elongation factor Tu domain 4 (1091 - 1162)

  • 0
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  • 1000
  • 1220 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 5B

  • eIF-5B

EIF5B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF5B O60841 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
EIF5B O60841 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
EIF5B O60841 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
EIF5B O60841 GRN Homo sapiens P28799
Validated Y2H
32814053
Intra
EIF5B O60841 GRN Homo sapiens P28799
Y2H Pooling
32814053
Intra
EIF5B O60841 GRN Homo sapiens P28799
Y2H Array
32814053
Intra
EIF5B O60841 ETS1 Homo sapiens P14921
TAP
20195357
Intra
EIF5B O60841 ETS1 Homo sapiens P14921
Display Tech
20195357
Intra
EIF5B O60841 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra
EIF5B O60841 PEX1 Homo sapiens O43933
Y2H Array
32814053
Intra
EIF5B O60841 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Inflammatory Liposarcoma
Acquired Color Blindness

  • Acquired Color Vision Deficiencies

  • Acquired Color Vision Deficiency

  • Acquired Colour Blindness

  • Acquired Colour Vision Deficiencies

  • Acquired Colour Vision Deficiency
Erythrocytosis, Familial, 2

  • Chuvash Polycythemia

  • ECYT2

  • Familial Erythrocytosis 2

  • Autosomal Recessive Benign Erythrocytosis

  • Polycythemia, Vhl-Dependent

  • Chuvash Erythromatosis

  • Chuvash Type Polycythemia

  • Chuvash Erythrocytosis

  • Von Hippel-Lindau-Dependent Polycythemia

  • Polycythemia Chuvash Type

  • Vhl-Dependent Polycythemia

  • Erythrocytosis, Familial, Type 2
Primary Polycythemia

  • Familial Erythrocytosis

  • Familiar Polycythemia

  • Benign Familial Polycythemia

  • Congenital Erythrocytosis

  • Familial Polycythemia

  • Hereditary Erythrocytosis

  • Primary Familial Polycythemia

  • Erythrocytosis, Familial

  • Polycythemia Vera

  • Primary Familial Polycythaemia

  • Primary Inherited Polycythaemia
Parameningeal Embryonal Rhabdomyosarcoma
Von Hippel-Lindau Syndrome

  • Von Hippel-Lindau Disease

  • Vhl

  • Vhl Syndrome

  • VHLS

  • Von Hippel-Lindau Syndrome, Modifier Of

  • Hippel Lindau Syndrome

  • Angiomatosis Retinae

  • Cerebelloretinal Angiomatosis, Familial

  • Hippel-Lindau Disease

  • Familial Cerebelloretinal Angiomatosis

  • Lindau Disease

  • VHLD
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04288 EIF5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22482 Eif5b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29005 Eif5b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EIF5B VGNC VGNC:28420
Mus musculus EIF5B MGD MGI:2441772
Felis catus EIF5B VGNC VGNC:61799
Rattus norvegicus EIF5B RGD RGD:735017
Macaca mulatta EIF5B VGNC VGNC:72148
Canis familiaris EIF5B VGNC VGNC:40294
Others EIF5B NCBI