TLK1 - tousled like kinase 1 Gene

Also Known as PKU-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9874

About TLK1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:170,990,823-171,231,293 (from NCBI)

This gene has 12 transcripts (splice variants), 292 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 13.5), thyroid (RPKM 10.7) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

TLK1 Products (3)

mRNA Protein Name
NM_001136554.2 NP_001130026.1 serine/threonine-protein kinase tousled-like 1 isoform 2
NM_001136555.2 NP_001130027.1 serine/threonine-protein kinase tousled-like 1 isoform 3
NM_012290.5 NP_036422.3 serine/threonine-protein kinase tousled-like 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
12660173 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12660173 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular protein transport IDA
IDA: Inferred from direct assay
10588641 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12660173 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12660173 GOA
involved in regulation of chromatin organization IDA
IDA: Inferred from direct assay
12660173 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10523312 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (458 - 734)

  • 0
  • 200
  • 400
  • 600
  • 766 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase tousled-like 1

  • SNARE protein kinase SNAK

TLK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TLK1 Q9UKI8 ZSCAN22 Homo sapiens P10073
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 ZSCAN22 Homo sapiens P10073
Y2H Array
32296183
Intra
TLK1 Q9UKI8 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
32296183
Intra
TLK1 Q9UKI8 TPM3 Homo sapiens Q5VU62
Validated Y2H
25416956
Intra
TLK1 Q9UKI8 TPM3 Homo sapiens Q5VU62
Y2H Array
25416956
Intra
TLK1 Q9UKI8 LUZP4 Homo sapiens Q9P127
Validated Y2H
25416956
Intra
TLK1 Q9UKI8 LUZP4 Homo sapiens Q9P127
Y2H Array
25416956
Intra
TLK1 Q9UKI8 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra
TLK1 Q9UKI8 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 YAF2 Homo sapiens Q8IY57-5
Y2H Array
32296183
Intra
TLK1 Q9UKI8 YAF2 Homo sapiens Q8IY57-5
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 LHX2 Homo sapiens P50458
Y2H Array
32296183
Intra
TLK1 Q9UKI8 LHX2 Homo sapiens P50458
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 ZNF829 Homo sapiens Q3KNS6-3
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 ZNF829 Homo sapiens Q3KNS6-3
Y2H Array
32296183
Intra
TLK1 Q9UKI8 ZNF773 Homo sapiens Q6PK81
Y2H Array
32296183
Intra
TLK1 Q9UKI8 ZNF773 Homo sapiens Q6PK81
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
TLK1 Q9UKI8 DPPA4 Homo sapiens Q7L190
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 DPPA4 Homo sapiens Q7L190
Y2H Array
32296183
Intra
TLK1 Q9UKI8 TFCP2 Homo sapiens Q12800
Y2H Array
32296183
Intra
TLK1 Q9UKI8 TFCP2 Homo sapiens Q12800
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 PINX1 Homo sapiens Q96BK5
Y2H Array
32296183
Intra
TLK1 Q9UKI8 PINX1 Homo sapiens Q96BK5
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 DYNLL2 Homo sapiens Q96FJ2
Pull Down
32707033
Intra
TLK1 Q9UKI8 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
TLK1 Q9UKI8 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
TLK1 Q9UKI8 ASF1A Homo sapiens Q9Y294
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TLK1 Proteins

Cat. No. Product Name Accession Purity
HY-P76676 TLK1 Protein, Human (sf9, His-GST) Q9UKI8 (M1-Y766) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pica Disease

  • Pica
Spermatogenic Failure 5

  • Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa

  • Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna

  • SPGF5

  • Macrocephalic Sperm Head Syndrome

  • Male Infertility Due To Macrozoospermia

  • Infertility Associated With Multitailed Spermatozoa And Excessive Dna

  • Macrozoospermia

  • Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa

  • Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid

  • Large-Headed Multiflagellar Polyploid Spermatozoa

  • Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149213 LSD1/TLK1-IN-1 Inhibitor 99.20% Unkown
HY-173186 TLK1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TLK1 VGNC VGNC:66211
Mus musculus TLK1 MGD MGI:2441683
Canis familiaris TLK1 VGNC VGNC:47398
Macaca mulatta TLK1 VGNC VGNC:78367
Rattus norvegicus TLK1 RGD RGD:1310370
Bos taurus TLK1 VGNC VGNC:35893
Others TLK1 NCBI