TLK1 - tousled like kinase 1 Gene

Homo sapiens

Also known as PKU-beta

Gene ID: 9874 | Gene type: protein coding

About TLK1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:170,990,823-171,231,293 (from NCBI)

This gene has 12 transcripts (splice variants), 292 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 13.5), thyroid (RPKM 10.7) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

TLK1 Products(3)

mRNA	Protein	Name
NM_001136554.2	NP_001130026.1	serine/threonine-protein kinase tousled-like 1 isoform 2
NM_001136555.2	NP_001130027.1	serine/threonine-protein kinase tousled-like 1 isoform 3
NM_012290.5	NP_036422.3	serine/threonine-protein kinase tousled-like 1 isoform 1

TLK1 Protein Structure

Pkinase

0
200
400
600
766 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase tousled-like 1

SNARE protein kinase SNAK

Recombinant TLK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76676	TLK1 Protein, Human (sf9, His-GST)	Q9UKI8 (M1-Y766)	≥95%

Related Diseases

Diseases

Alias

Pica Disease

Pica

Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa	Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna
SPGF5	Macrocephalic Sperm Head Syndrome
Male Infertility Due To Macrozoospermia	Infertility Associated With Multitailed Spermatozoa And Excessive Dna
Macrozoospermia	Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa
Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid	Large-Headed Multiflagellar Polyploid Spermatozoa
Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14570	TLK1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TLK1	VGNC	VGNC:66211
Mus musculus	TLK1	MGD	MGI:2441683
Canis familiaris	TLK1	VGNC	VGNC:47398
Macaca mulatta	TLK1	VGNC	VGNC:78367
Rattus norvegicus	TLK1	RGD	RGD:1310370
Bos taurus	TLK1	VGNC	VGNC:35893
Others	TLK1	NCBI