TMCC2 - transmembrane and coiled-coil domain family 2 Gene

Homo sapiens

Also known as HUCEP11

Gene ID: 9911 | Gene type: protein coding

About TMCC2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,227,946-205,273,343 (from NCBI)

This gene has 10 transcripts (splice variants), 222 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 19.2), brain (RPKM 7.1) and 4 other tissues.

Summary

Involved in amyloid precursor protein metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

TMCC2 Products(7)

mRNA	Protein	Name
NM_001242925.2	NP_001229854.1	transmembrane and coiled-coil domains protein 2 isoform 2
NM_001297611.2	NP_001284540.1	transmembrane and coiled-coil domains protein 2 isoform 3
NM_001297613.2	NP_001284542.1	transmembrane and coiled-coil domains protein 2 isoform 4
NM_001331034.1	NP_001317963.1	transmembrane and coiled-coil domains protein 2 isoform 5
NM_001375651.1	NP_001362580.1	transmembrane and coiled-coil domains protein 2 isoform 2
NM_001375652.1	NP_001362581.1	transmembrane and coiled-coil domains protein 2 isoform 2
NM_014858.4	NP_055673.2	transmembrane and coiled-coil domains protein 2 isoform 1

TMCC2 Protein Structure

Tmemb_cc2

0
200
400
600
709 a.a.

Protein Preferred Names

Protein Names

transmembrane and coiled-coil domains protein 2

cerebral protein 11

Related Diseases

Diseases

Alias

Noonan Syndrome 10

NS10	Noonan Syndrome, Type 10

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14630	TMCC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMCC2	VGNC	VGNC:66240
Mus musculus	TMCC2	MGD	MGI:1916125
Canis familiaris	TMCC2	VGNC	VGNC:47429
Bos taurus	TMCC2	VGNC	VGNC:35926
Macaca mulatta	TMCC2	VGNC	VGNC:79423
Rattus norvegicus	TMCC2	RGD	RGD:1311960

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