TMCC2 - transmembrane and coiled-coil domain family 2 Gene

Also Known as HUCEP11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9911

About TMCC2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,227,946-205,273,343 (from NCBI)

This gene has 10 transcripts (splice variants), 222 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 19.2), brain (RPKM 7.1) and 4 other tissues.

Summary

Involved in amyloid precursor protein metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

TMCC2 Products (7)

mRNA Protein Name
NM_001242925.2 NP_001229854.1 transmembrane and coiled-coil domains protein 2 isoform 2
NM_001297611.2 NP_001284540.1 transmembrane and coiled-coil domains protein 2 isoform 3
NM_001297613.2 NP_001284542.1 transmembrane and coiled-coil domains protein 2 isoform 4
NM_001331034.1 NP_001317963.1 transmembrane and coiled-coil domains protein 2 isoform 5
NM_001375651.1 NP_001362580.1 transmembrane and coiled-coil domains protein 2 isoform 2
NM_001375652.1 NP_001362581.1 transmembrane and coiled-coil domains protein 2 isoform 2
NM_014858.4 NP_055673.2 transmembrane and coiled-coil domains protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21593558 GOA
Biological Process GO Annotation Evidence References Source
involved in amyloid precursor protein metabolic process IDA
IDA: Inferred from direct assay
21593558 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21593558 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMCC2 Protein Structure

Tmemb_cc2

Tmemb_cc2: Predicted transmembrane and coiled-coil 2 protein (284 - 697)

  • 0
  • 200
  • 400
  • 600
  • 709 a.a.
Protein Preferred Names Protein Names

transmembrane and coiled-coil domains protein 2

  • cerebral protein 11

TMCC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMCC2 O75069 APOE Homo sapiens P02649
Anti Tag CoIP
21593558
Intra
TMCC2 O75069 APOE Homo sapiens P02649
Y2H
21593558
Intra
TMCC2 O75069 APOE Homo sapiens P02649
Fluorescence Spectr
21593558
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome 10

  • NS10

  • Noonan Syndrome, Type 10
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14630 TMCC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMCC2 VGNC VGNC:66240
Mus musculus TMCC2 MGD MGI:1916125
Canis familiaris TMCC2 VGNC VGNC:47429
Bos taurus TMCC2 VGNC VGNC:35926
Macaca mulatta TMCC2 VGNC VGNC:79423
Rattus norvegicus TMCC2 RGD RGD:1311960
Others TMCC2 NCBI