Glycochenodeoxycholic acid sodium salt (Standard)
Based on 1 Customer Validation
Glycochenodeoxycholic acid sodium salt (Standard) is the analytical standard of Glycochenodeoxycholic acid sodium salt. This product is intended for research and analytical applications. Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC).
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 16564-43-5
- Formula: C26H42NNaO5
- Molecular Weight:471.61
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Purity & Documentation
-
Help & FAQs
-
HY-19696
Tauroursodeoxycholate
-
HY-N0324R
Cholic acid (Standard)
-
HY-B0172R
Lithocholic acid (Standard)
-
HY-N1429R
Taurochenodeoxycholic acid sodium (Standard)
-
HY-113308A
Taurolithocholic acid sodium salt
-
HY-N2334A
Glycochenodeoxycholic acid sodium salt
-
HY-N1424R
Glycoursodeoxycholic acid (Standard)
-
HY-19696AR
Tauroursodeoxycholate sodium (Standard)
-
HY-N0324
Cholic acid
-
HY-B0172
Lithocholic acid
-
HY-N0324A
Cholic acid sodium
-
HY-N1429
Taurochenodeoxycholic acid sodium
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 16564-43-5
-
Appearance Solid
-
Molecular Weight 471.61
-
Formula C26H42NNaO5
-
Color White to off-white
-
SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCC(O[Na])=O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C[C@H](O)CC4)([H])C[C@H]3O)C)([H])CC1
-
Synonyms
Chenodeoxycholylglycine sodium salt (Standard); Sodium glycochenodeoxycholate (Standard)
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Lan W, et al. Glycochenodeoxycholic acid sodium salt impairs transcription factor E3 -dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells[J]. Toxicol Lett. 2020 Oct 1;331:11-21. [Content Brief]
[2]. Wang A, et al. Glycochenodeoxycholic acid sodium salt Does Not Increase Transforming Growth Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis in Myofibroblasts[J]. J Clin Exp Hepatol. 2017 Dec;7(4):316-320. [Content Brief]
[3]. Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207(1-2):19-27. [Content Brief]
[4]. Shi C, et al. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells[J]. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glycochenodeoxycholic acid sodium salt (Standard) Related Classifications
HY-N2334AR Related Classifications
Powered by Bioz
- Glycochenodeoxycholic acid sodium salt (Standard)
- 16564-43-5
- Chenodeoxycholylglycine sodium salt (Standard)
- Sodium glycochenodeoxycholate (Standard)
- Reference Standards
- Endogenous Metabolite
- Apoptosis
- STAT
- BCL6
- Interleukin Related
- Caspase
- bile salt
- hepatocellular carcinoma cells
- autophagosome inhibition
- STAT3 signaling pathway
- cholestasis desease
- primary sclerosing cholangitis
- Inhibitor
- inhibitor
- inhibit