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Cat. No.: HY-N2863

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Goniothalenol

Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines.

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CAS No.: 65408-91-5
Formule: C₁₃H₁₂O₄
Masse moléculaire:232.23

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Goniothalenol Chemical Structure

CAS No.: 65408-91-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	19 μM Compound: 6	Antiproliferative activity against human CEM cells after 48 hrs by SRB assay Antiproliferative activity against human CEM cells after 48 hrs by SRB assay	[PMID: 20036566]
L1210	IC₅₀	2.9 μg/mL Compound: 1	Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay	[PMID: 10479313]
MCF-12A	IC₅₀	120 μM Compound: 6	Cytotoxicity against human MCF12A cells after 48 hrs by SRB assay Cytotoxicity against human MCF12A cells after 48 hrs by SRB assay	[PMID: 20036566]
MCF7	IC₅₀	124 μM Compound: 6	Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 20036566]
RAW264.7	IC₅₀	0.8 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 23735825]
RAW264.7	IC₅₀	0.8 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IFN-beta mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IFN-beta mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	0.9 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-6 mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-6 mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	2 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced iNOS mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced iNOS mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	3 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced COX2 mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced COX2 mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	3 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-1beta mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-1beta mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	4 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced G-CSF mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced G-CSF mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	4 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced MCP1 mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced MCP1 mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	43.4 μM Compound: 2	Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay	[PMID: 23735825]
RAW264.7	IC₅₀	5 μM Compound: 2	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IP-10 mRNA expression by quantitative real-time PCR analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IP-10 mRNA expression by quantitative real-time PCR analysis	[PMID: 23735825]
RAW264.7	IC₅₀	6.7 μM Compound: 2	Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay	[PMID: 23735825]

Chemical Information

CAS No. 65408-91-5
Masse moléculaire 232.23
Formule C₁₃H₁₂O₄
SMILES

O[C@@H]1[C@@H](C2=CC=CC=C2)O[C@]3([H])[C@@]1([H])OC(C=C3)=O
Structure Classification
- Others
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang, Y. J., et al. Styryllactones from the Rhizomes ofGoniothalamus griffithii. Journal of Asian Natural Products Research, 1(3), 189–197.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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