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    Stem Cell/Wnt
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  3. GS87

GS87 

Cat. No.: HY-134557
Handling Instructions

GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research.

For research use only. We do not sell to patients.

GS87 Chemical Structure

GS87 Chemical Structure

CAS No. : 919936-70-2

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Description

GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research[1].

IC50 & Target[1]

GSK3α

415 nM (IC50)

GSK3β

521 nM (IC50)

Molecular Weight

337.36

Formula

C16H11N5O2S

CAS No.
SMILES

C1(C2=NN=C(SCC3=NC(C4=CC=CC=C4)=NO3)O2)=CC=NC=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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GS87
Cat. No.:
HY-134557
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