GSK-3β-IN-29
GSK-3β-IN-29 is a selective GSK-3β inhibitor with an IC50 of 34.0 nM. GSK-3β-IN-29 shows selectivity for GSK-3β over 40 other kinases and for 5-HT1a receptor. GSK-3β-IN-29 exhibits neuroprotection in mice. GSK-3β-IN-29 can be used for the research of nervous system (CNS) disorders.
For research use only. We do not sell to patients.
- CAS No.: 871843-09-3
- Formula: C21H18N4O
- Molecular Weight:342.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GSK-3β 34.0 nM (IC50) |
GSK-3β-IN-29 (compound 3a) (10-100 μM) shows high selectivity for GSK-3β and GSK-3α over 40 other purified kinases, with selectivity indexes >53 for all non-GSK-3 kinases tested[1].
GSK-3β-IN-29 (50 nM-20 μM; 48 h) provides dose-dependent neuroprotection to neurons against homocysteic acid (HCA)-induced oxidative stress without toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:neurons exposed to homocysteic acid-induced oxidative stress
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Concentration:50; 100; 150; 200; 500 nM; 1; 5; 20 μM
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Incubation Time:48 h
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Result:Showed full neuroprotective activity at concentrations from 1 μM to 20 μM with no observable toxicity.
Achieved nearly complete protection against HCA-induced cell death at 150 nM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice (male, 8 weeks old)[1]
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Dosage:150 mg/kg
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Administration:i.p.; single dose
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Result:Attenuated locomotor activity induced by the Amphetamine + Chlordiazepoxide mixture.
Did not affect locomotor activity induced by amphetamine alone.
Chemical Information
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CAS No. 871843-09-3
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Molecular Weight 342.39
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Formula C21H18N4O
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SMILES
O=C1NNC(C2=CN(C)C3=C2C=CC=C3)=C1C4=CN(C)C5=C4C=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK-3β-IN-29 Related Classifications
HY-183908 Related Classifications
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