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Cat. No.: HY-162638

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GSK-3β inhibitor 18

GSK-3β inhibitor 18 (compound 2) is a potent inhibitor of GSK-3β, with the IC₅₀ of 0.0021 μM.

For research use only. We do not sell to patients.

Formula: C₂₅H₂₁N₅O₄
Molecular Weight:455.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

GSK-3β inhibitor 18 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

GSK-3β inhibitor 18 (compound 2) is a potent inhibitor of GSK-3β, with the IC₅₀ of 0.0021 μM^[1].

IC₅₀ & Target

GSK-3β

0.0021 μM (IC₅₀)

All GSK-3 Isoforms :

Chemical Information

Molecular Weight 455.47
Formula C₂₅H₂₁N₅O₄
SMILES

CC1=CN=CN1CCCN(C2=C3C=CC=C2)C=C3C(C(NC4=O)=O)=C4C5=CC=CC=C5[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dingjun Wei, et al. Structure-activity relationship of dual inhibitors containing maleimide and imidazole motifs against glutaminyl cyclase and glycogen synthase kinase-3β. Bioorg Med Chem Lett. 2024 Jun 19:110:129851. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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GSK-3β inhibitor 18

All GSK-3 Isoforms