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Cat. No.: HY-162913

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GSK-3β inhibitor 20

GSK-3β inhibitor 20 (compound 3A) is an potent inhibitor of GSK-3β with an IC₅₀ value of 74.4 nM.

For research use only. We do not sell to patients.

CAS No.: 3044109-48-7
Formula: C₂₂H₂₁N₅O₂S
Molecular Weight:419.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

GSK-3β inhibitor 20 Chemical Structure

CAS No.: 3044109-48-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

GSK-3β inhibitor 20 (compound 3A) is an potent inhibitor of GSK-3β with an IC₅₀ value of 74.4 nM^[1].

All GSK-3 Isoforms :

Chemical Information

CAS No. 3044109-48-7
Molecular Weight 419.50
Formula C₂₂H₂₁N₅O₂S
SMILES

O=C(NC1=CC=CC=C1)NC2=CC(C3=CC(NN=C4NC(C(C)C)=O)=C4S3)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ning Yan, et al. Design, synthesis and biological evaluation of thieno[3,2-c]pyrazol-urea derivatives as potent glycogen synthase kinase 3β inhibitors based on the DFG-out conformation. Bioorg Med Chem Lett. 2024 Nov 1:112:129932. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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GSK-3β inhibitor 20

All GSK-3 Isoforms