GSK-3β inhibitor 8
Based on 1 Customer Validation
GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation.
For research use only. We do not sell to patients.
- Purity : 98.16%
- CAS No.: 1139875-74-3
- Formula: C20H20ClN5OS
- Molecular Weight:413.92
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
GSK-3β 64 nM (IC50) |
In Vitro
GSK-3β inhibitor 8 (compound 1a) (1 nM-100 μM; 7 d) dose-dependently stimulates β-cell proliferation with an EC50 value of 1.41 μM. And GSK-3β inhibitor 8 (2 μM; 72 h) increases the replicating R7T1 β cells about 2-fold[1].
GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) induces the activation of Super (8X) TOPFlash reporter with an EC50 value of 1.25 μM[1].
GSK-3β inhibitor 8 (2 μM; 72 h) stimulates the translocation of β-catenin into the nucleus in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1139875-74-3
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Appearance Solid
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Molecular Weight 413.92
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Formula C20H20ClN5OS
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Color White to off-white
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SMILES
O=C(C1=CC=C(NC2=NC=CC(C3=CC=CS3)=N2)C=C1Cl)N4CCN(C)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (241.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4159 mL | 12.0796 mL | 24.1593 mL | 60.3981 mL |
| 5 mM | 0.4832 mL | 2.4159 mL | 4.8319 mL | 12.0796 mL | |
| 10 mM | 0.2416 mL | 1.2080 mL | 2.4159 mL | 6.0398 mL | |
| 15 mM | 0.1611 mL | 0.8053 mL | 1.6106 mL | 4.0265 mL | |
| 20 mM | 0.1208 mL | 0.6040 mL | 1.2080 mL | 3.0199 mL | |
| 25 mM | 0.0966 mL | 0.4832 mL | 0.9664 mL | 2.4159 mL | |
| 30 mM | 0.0805 mL | 0.4027 mL | 0.8053 mL | 2.0133 mL | |
| 40 mM | 0.0604 mL | 0.3020 mL | 0.6040 mL | 1.5100 mL | |
| 50 mM | 0.0483 mL | 0.2416 mL | 0.4832 mL | 1.2080 mL | |
| 60 mM | 0.0403 mL | 0.2013 mL | 0.4027 mL | 1.0066 mL | |
| 80 mM | 0.0302 mL | 0.1510 mL | 0.3020 mL | 0.7550 mL | |
| 100 mM | 0.0242 mL | 0.1208 mL | 0.2416 mL | 0.6040 mL |
GSK-3β inhibitor 8 Related Classifications
HY-120902 Related Classifications
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