GSK-3β inhibitor 8
Based on 1 Customer Validation
GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation.
For research use only. We do not sell to patients.
- Purity: 98.16%
- CAS No.: 1139875-74-3
- Formula: C20H20ClN5OS
- Molecular Weight:413.92
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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GSK-3β 64 nM (IC50) |
GSK-3β inhibitor 8 (compound 1a) (1 nM-100 μM; 7 d) dose-dependently stimulates β-cell proliferation with an EC50 value of 1.41 μM. And GSK-3β inhibitor 8 (2 μM; 72 h) increases the replicating R7T1 β cells about 2-fold[1].
GSK-3β inhibitor 8 (1 nM-100 μM; 24 h) induces the activation of Super (8X) TOPFlash reporter with an EC50 value of 1.25 μM[1].
GSK-3β inhibitor 8 (2 μM; 72 h) stimulates the translocation of β-catenin into the nucleus in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1139875-74-3
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Appearance Solid
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Molecular Weight 413.92
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Formula C20H20ClN5OS
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Color White to off-white
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SMILES
O=C(C1=CC=C(NC2=NC=CC(C3=CC=CS3)=N2)C=C1Cl)N4CCN(C)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)