GSK-J1 sodium
GSK-J1 sodium is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 value of 60 nM towards KDM6B.
For research use only. We do not sell to patients.
- CAS No.: 1797832-71-3
- Formula: C22H22N5NaO2
- Molecular Weight:411.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-15648F
GSK-J4 hydrochlorideJMJD3/UTX Inhibitor -
HY-101928
KDM4D-IN-1KDM4D Inhibitor -
HY-107573
KDM2/7-IN-1KDM2/7 Inhibitor -
HY-13953
JIB-04Histone Demethylase Inhibitor -
HY-12725
ML324JMJD2 Inhibitor -
HY-12635
SP2509LSD1 Antagonist -
HY-15648I
GSK-J2 sodiumInactive Isomer of GSK-J1 -
HY-135146
GSK-3484862DNMT1 Inhibitor -
HY-100744
AS8351KDM5B Inhibitor -
HY-15648B
GSK-J4JMJD3/UTX Inhibitor -
HY-15648FR
GSK-J4 hydrochloride (Standard)JMJD3/UTX Inhibitor -
HY-101928R
KDM4D-IN-1 (Standard)Reference Standard
Biological Activity
Description
IC50 & Target
IC50: 60 nM (KDM6B)[2]
Chemical Information
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CAS No. 1797832-71-3
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Molecular Weight 411.43
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Formula C22H22N5NaO2
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SMILES
O=C(CCNC1=CC(N2CCC3=C(CC2)C=CC=C3)=NC(C4=CC=CC=N4)=N1)O[Na]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8. [Content Brief]
[2]. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2. [Content Brief]
[3]. Horton JR, et al. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb 5;291(6):2631-46. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK-J1 sodium Related Classifications
HY-15648G Related Classifications
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