GSPT1 degrader-5
GSPT1 degrader-5 is a GSPT1 molecular glue degrader that recruits cereblon (CRBN), with a DC50 of 20 nM. GSPT1 degrader-5 induces GSPT1 protein degradation via the ubiquitin-proteasome pathway. GSPT1 degrader-5 can be used in breast cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 3034764-38-7
- Formula: C24H18F4N4O6
- Molecular Weight:534.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
GSPT1 degrader-5 (compound 5) (6 h) induces concentration-dependent degradation of GSPT1 protein in CAL51 breast cancer cells, with a DC50 of 20 nM and a maximum degradation rate of 96.7%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3034764-38-7
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Molecular Weight 534.42
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Formula C24H18F4N4O6
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SMILES
O=C(OCC1=CC=C2C(C=C(CN3C4C(NC(CC4)=O)=O)N2C3=O)=C1)NC5=C(F)C=CC(OC(F)(F)F)=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSPT1 degrader-5 Related Classifications
HY-162534 Related Classifications
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