H-Gly-Pro-Gly-NH2
H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits HIV-1 replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 IIIB and HIV-2 ROD with EC50 values of 35 µM and 30 µM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research.
For research use only. We do not sell to patients.
- CAS No.: 141497-12-3
- Formula: C9H16N4O3
- Molecular Weight:228.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[3]|
HIV (IIIB) 35 μM (EC50) |
HIV-2 (ROD) 30 μM (EC50) |
In Vitro
H-Gly-Pro-Gly-NH2 (5, 20 and 100 µM) shows antiviral activities in HUT78 cells infected with HIV-1 SF-2[1].
H-Gly-Pro-Gly-NH2 (100 µM) destroys the capsid of HIV-1 virus particles in ACH-2 cells[1].
Antiviral activity of H-Gly-Pro-Gly-NH2 against clinical HIV-1[2]
| T215Y/F | K70R | M184V | L74V | T69D | |||||||||
| Mean IC50 (µM) | 16 | 17 | 20 | 12 | 17 | ||||||||
| K103N | Y181C | G48V | L90M | V82A/T | M46I/L | |
| Mean IC50 (µM) | 13 | 21 | 16 | 18 | 16 | 17 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 141497-12-3
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Molecular Weight 228.25
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Formula C9H16N4O3
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Sequence
H-Gly-Pro-Gly-NH2
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Sequence Shortening
GPG-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Höglund S, et al. Tripeptide interference with human immunodeficiency virus type 1 morphogenesis. Antimicrob Agents Chemother. 2002 Nov;46(11):3597-605. [Content Brief]
[3]. Balzarini J, et al. Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)). Int J Biochem Cell Biol. 2004 Sep;36(9):1848-59. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
H-Gly-Pro-Gly-NH2 Related Classifications
HY-P4292 Related Classifications
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Keywords