1. Anti-infection
  2. HBV

Helioxanthin derivative 5-4-2 (Synonyms: Helioxanthin 5-4-2)

Cat. No.: HY-16679 Purity: 99.76%
Handling Instructions

Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells.

For research use only. We do not sell to patients.

Helioxanthin derivative 5-4-2 Chemical Structure

Helioxanthin derivative 5-4-2 Chemical Structure

CAS No. : 203935-39-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells. IC50 value: 0.08 uM (EC50) [1][2] Target: Anti-HBV Helioxanthin derivative 5-4-2 had potent anti-HBV activities in HepG2.2.15 cells, with the EC50s of 1 and 0.08 microM, respectively. The lamivudine-resistant HBV, L526M/M550V double mutant strain, was also sensitive to helioxanthin and 5-4-2. This class of compounds not only inhibited HBV DNA, but also decreased HBV mRNA and HBV protein expression. The EC50 of HBV DNA inhibition was consistent with the EC50 of HBV 3.5 Kb transcript inhibition, which was 1 and 0.09 microM for helioxanthin and 5-4-2 respectively.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.8792 mL 14.3959 mL 28.7919 mL
5 mM 0.5758 mL 2.8792 mL 5.7584 mL
10 mM 0.2879 mL 1.4396 mL 2.8792 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

347.32

Formula

C₂₀H₁₃NO₅

CAS No.

203935-39-1

SMILES

O=C1NCC2=C(C3=CC=C(OCO4)C4=C3)C5=C6C(OCO6)=CC=C5C=C21

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.76%

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Product Name:
Helioxanthin derivative 5-4-2
Cat. No.:
HY-16679
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