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Helioxanthin derivative 5-4-2 Chemical Structure
|Product name: Helioxanthin derivative 5-4-2|
|Cat. No.: HY-16679|
Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells.
IC50 value: 0.08 uM (EC50) 
Helioxanthin derivative 5-4-2 had potent anti-HBV activities in HepG2.2.15 cells, with the EC50s of 1 and 0.08 microM, respectively. The lamivudine-resistant HBV, L526M/M550V double mutant strain, was also sensitive to helioxanthin and 5-4-2. This class of compounds not only inhibited HBV DNA, but also decreased HBV mRNA and HBV protein expression. The EC50 of HBV DNA inhibition was consistent with the EC50 of HBV 3.5 Kb transcript inhibition, which was 1 and 0.09 microM for helioxanthin and 5-4-2 respectively.
|M.Wt||347.32||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||2.8792 mL||14.3959 mL||28.7919 mL|
|5 mM||0.5758 mL||2.8792 mL||5.7584 mL|
|10 mM||0.2879 mL||1.4396 mL||2.8792 mL|
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