1. Anti-infection
  2. HBV
  3. Helioxanthin derivative 5-4-2

Helioxanthin derivative 5-4-2  (Synonyms: Helioxanthin 5-4-2)

Cat. No.: HY-16679 Purity: 99.80%
COA Handling Instructions

Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.

For research use only. We do not sell to patients.

Helioxanthin derivative 5-4-2 Chemical Structure

Helioxanthin derivative 5-4-2 Chemical Structure

CAS No. : 203935-39-1

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5 mg USD 1100 In-stock
10 mg USD 1750 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Helioxanthin derivative 5-4-2:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Helioxanthin derivative 5-4-2

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  • Purity & Documentation

  • References

  • Customer Review

Description

Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells. IC50 value: 0.08 uM (EC50) [1][2] Target: Anti-HBV Helioxanthin derivative 5-4-2 had potent anti-HBV activities in HepG2.2.15 cells, with the EC50s of 1 and 0.08 microM, respectively. The lamivudine-resistant HBV, L526M/M550V double mutant strain, was also sensitive to helioxanthin and 5-4-2. This class of compounds not only inhibited HBV DNA, but also decreased HBV mRNA and HBV protein expression. The EC50 of HBV DNA inhibition was consistent with the EC50 of HBV 3.5 Kb transcript inhibition, which was 1 and 0.09 microM for helioxanthin and 5-4-2 respectively.

Molecular Weight

347.32

Formula

C20H13NO5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NCC2=C(C3=CC=C(OCO4)C4=C3)C5=C6C(OCO6)=CC=C5C=C21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (143.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8792 mL 14.3959 mL 28.7919 mL
5 mM 0.5758 mL 2.8792 mL 5.7584 mL
10 mM 0.2879 mL 1.4396 mL 2.8792 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.20 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.80%

References
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Helioxanthin derivative 5-4-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Helioxanthin derivative 5-4-2
Cat. No.:
HY-16679
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