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Helioxanthin derivative 5-4-2

HY-16679

(Helioxanthin 5-4-2)

Helioxanthin derivative 5-4-2

Helioxanthin derivative 5-4-2 Chemical Structure

Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells.

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Product name: Helioxanthin derivative 5-4-2
Cat. No.: HY-16679

Helioxanthin derivative 5-4-2 Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Helioxanthin derivative 5-4-2

Helioxanthin derivative 5-4-2 is an analogue of  helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells.
IC50 value: 0.08 uM (EC50) [1][2]
Target: Anti-HBV
Helioxanthin derivative 5-4-2 had potent anti-HBV activities in HepG2.2.15 cells, with the EC50s of 1 and 0.08 microM, respectively. The lamivudine-resistant HBV, L526M/M550V double mutant strain, was also sensitive to helioxanthin and 5-4-2. This class of compounds not only inhibited HBV DNA, but also decreased HBV mRNA and HBV protein expression. The EC50 of HBV DNA inhibition was consistent with the EC50 of HBV 3.5 Kb transcript inhibition, which was 1 and 0.09 microM for helioxanthin and 5-4-2 respectively.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 347.32 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₀H₁₃NO₅
CAS No 203935-39-1
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.8792 mL 14.3959 mL 28.7919 mL
5 mM 0.5758 mL 2.8792 mL 5.7584 mL
10 mM 0.2879 mL 1.4396 mL 2.8792 mL

References on Helioxanthin derivative 5-4-2

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