Hercynylcysteine sulfoxide
Hercynylcysteine sulfoxide is a synthetic precursor of Ergothioneine (HY-N1914), and it spontaneously converts to Ergothioneine in the presence of pyridoxal phosphate (PLP). Hercynylcysteine sulfoxide is produced via the fusion enzyme complex NcEgt1‑1/CtEgtB-catalyzed conversion of L-histidine and L-cysteine, and serves as an intermediate in the ergothioneine biosynthetic pathway of Schizosaccharomyces pombe and engineered Escherichia coli BL21 (DE3).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1227698-30-7
- Formule: C12H20N4O5S
- Masse moléculaire:332.38
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform Endogenous Metabolite
More
Activité biologique
Description
In Vitro
Hercynylcysteine sulfoxide is undetectable in wild-type Schizosaccharomyces pombe cells under vegetative growth conditions; it accumulates in egt2Δ deletion mutant Schizosaccharomyces pombe cells cultured under vegetative growth, nitrogen starvation, or glucose starvation conditions for 24 hours[1].
Hercynylcysteine sulfoxide accumulates in Schizosaccharomyces pombe egt1+ overexpression strains in a promoter strength-dependent manner under thiamine-free culture conditions; it accumulates in large quantities in Schizosaccharomyces pombe P3nmt1-egt1+ Δegt2 double mutant cells cultured in selenium-supplemented medium[1].
Hercynylcysteine sulfoxide is a transient biosynthetic intermediate produced by engineered Escherichia coli BL21 (DE3) via a two-step consecutive enzymatic reaction involving NcEgt1-1 and CtEgtB[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
-
CAS No. 1227698-30-7
-
Masse moléculaire 332.38
-
Formule C12H20N4O5S
-
SMILES
C[N+](C)(C)[C@H](C([O-])=O)CC1=CN=C(S(C[C@H](N)C(O)=O)=O)N1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hercynylcysteine sulfoxide Related Classifications
HY-189490 Related Classifications
Powered by Bioz
Keywords
- Hercynylcysteine sulfoxide
- 1227698-30-7
- Drug Intermediate
- Endogenous Metabolite
- Escherichia coli BL21 (DE3)
- ergothioneine
- NcEgt1-1/CtEgtB enzyme complex
- Schizosaccharomyces pombe
- Δegt2 deletion mutant
- egt1+ overexpression strains
- L-histidine
- L-cysteine
- pyridoxal phosphate
- P3nmt1-egt1+ strain
- Inhibitor
- inhibitor
- inhibit