NVP-DFF332
Based on 1 Customer Validation
HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity.
For research use only. We do not sell to patients.
- Purity: 99.31%
- CAS No.: 2734922-78-0
- Formula: C17H11ClF7N3O
- Molecular Weight:441.73
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 9 nM (HIF2α SPA); 37 nM (HIF2α iScript); 246 nM (HIF2α HRE RGA)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-9 weeks, female nude Crl:NU(NCr)-Foxn1nu-Homozygous mice (786-O mouse model)[1]
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Dosage:30 mg/kg
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Administration:P.o.; started 34 days post tumor inoculation; daily for 21 days
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Result:Inhibited the tumor growth.
Chemical Information
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CAS No. 2734922-78-0
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Appearance Solid
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Molecular Weight 441.73
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Formula C17H11ClF7N3O
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Color White to off-white
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SMILES
FC1(C2=C(Cl)N=CC=C2[C@]3(CC1)N=C4N(C=C(C=C4OC(F)F)C(F)(F)F)C3)F
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Synonyms
HIF-2α-IN-8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (565.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2638 mL | 11.3191 mL | 22.6383 mL | 56.5957 mL |
| 5 mM | 0.4528 mL | 2.2638 mL | 4.5277 mL | 11.3191 mL | |
| 10 mM | 0.2264 mL | 1.1319 mL | 2.2638 mL | 5.6596 mL | |
| 15 mM | 0.1509 mL | 0.7546 mL | 1.5092 mL | 3.7730 mL | |
| 20 mM | 0.1132 mL | 0.5660 mL | 1.1319 mL | 2.8298 mL | |
| 25 mM | 0.0906 mL | 0.4528 mL | 0.9055 mL | 2.2638 mL | |
| 30 mM | 0.0755 mL | 0.3773 mL | 0.7546 mL | 1.8865 mL | |
| 40 mM | 0.0566 mL | 0.2830 mL | 0.5660 mL | 1.4149 mL | |
| 50 mM | 0.0453 mL | 0.2264 mL | 0.4528 mL | 1.1319 mL | |
| 60 mM | 0.0377 mL | 0.1887 mL | 0.3773 mL | 0.9433 mL | |
| 80 mM | 0.0283 mL | 0.1415 mL | 0.2830 mL | 0.7074 mL | |
| 100 mM | 0.0226 mL | 0.1132 mL | 0.2264 mL | 0.5660 mL |
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