HIV-IN-16
HIV-IN-16 is a HIV replication inhibitor with an EC50 of 25 pM, and shows no activity in inducing CYP2B6. HIV-IN-16 inhibits HIV replication. HIV-IN-16 can be used in studies related to HIV infection and human immunodeficiency diseases.
For research use only. We do not sell to patients.
- CAS No.: 2570323-59-8
- Formula: C37H29ClF9N9O5S
- Molecular Weight:918.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV 25 pM (EC50) |
HIV-IN-16 (Example 1) (1 μM; up to 60 min) exhibits high stability in liver microsomes, with a half-life of >120 minutes in human, rat and monkey liver microsomes, and a half-life of 105 minutes in dog liver microsomes[1].
HIV-IN-16 exhibits high stability in human hepatocytes, with a half-life of over 480 min and an intrinsic clearance rate of 0.312 mL/min/g liver[1].
HIV-IN-16 does not induce CYP2B6 expression in primary human hepatocytes from three independent donors, and shows no cytotoxicity at the highest concentration of 30 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 mice (male); Wistar Han Rats (male); Cynomolgus monkeys (male); Beagle Dogs (male)[1]
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Dosage:1 mg/kg (i.v.); 5 mg/kg (p.o.)
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Administration:i.v.; p.o.
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Result:Recorded intravenous clearance values of 0.50 mL/min/kg (mouse), 2.64 mL/min/kg (rat), 8.50 mL/min/kg (monkey), and 1.68 mL/min/kg (dog).
Recorded steady-state volume of distribution values of 0.24 L/kg (mouse), 3.34 L/kg (rat), 1.18 L/kg (monkey), and 0.83 L/kg (dog).
Recorded apparent elimination half-life values of 7.6 h (mouse), 17.4 h (rat), 3.0 h (monkey), and 8.6 h (dog).
Chemical Information
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CAS No. 2570323-59-8
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Molecular Weight 918.19
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Formula C37H29ClF9N9O5S
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SMILES
O=C1C2=C(N=C(C(CC3=CC(F)=CC(F)=C3)NC(CN4N=C(C(F)F)C5=C4C(F)(C6CC56)F)=O)N1C7=CC=C(C8=C7N(C)N=C8NS(=O)(C)=O)Cl)N=C(OCCC(F)(F)F)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-IN-16 Related Classifications
HY-184864 Related Classifications
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