Blapsin B
Blapsin B is a potent 14-3-3 inhibitor and a naturally occurring compound from Blaps japanensis. Blapsin B potently inhibits 14-3-3 protein-protein interactions (PPIs) with an IC50 value of 10.0 μM in the ELISA assay and 2.5 μM in the FP assay, respectively. Blapsin B modulates signaling pathways involved in cell proliferation and transformation. Blapsin B can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 861145-00-8
- Formula: C15H14O5
- Molecular Weight:274.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Blapsin B (10 μM) potently inhibits 14-3-3γ protein-protein interactions in an ELISA assay with an IC50 of 10.0 μM[1].
Blapsin B (2.5 μM) potently inhibits 14-3-3 protein-protein interactions in an FP assay with an IC50 of 2.5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 861145-00-8
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Molecular Weight 274.27
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Formula C15H14O5
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SMILES
OC1=CC=C(C2OCCC3=CC(O)=C(C=C32)O)C=C1O
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Structure Classification
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Initial Source
from the insect Blaps japanensis
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Blapsin B Related Classifications
HY-N19296 Related Classifications
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