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Cat. No.: HY-160192

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KDO

Name: KDO
Brand: MedChemExpress
SKU: HY-160192
Availability: PreOrder

(Synonyms: 3-Deoxy-D-manno-2-octulosonic acid)

KDO (3-Deoxy-D-manno-2-octulosonic acid) is a characteristic monosaccharide component of capsular polysaccharides of Gram-negative bacteria and meningococcal lipooligosaccharide (LOS), and can also be present in the polysaccharide components of Nelumbo nucifera. KDO together with lipid A constitutes the LOS inner core and is an essential molecule for CD14/TLR4-mediated proinflammatory signaling. KDO can be used in research related to meningococcal disease and inflammation.

For research use only. We do not sell to patients.

CAS No.: 10149-14-1
Formula: C₈H₁₄O₈
Molecular Weight:238.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KDO Chemical Structure

CAS No.: 10149-14-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Bacterial Infection

The KDO-positive rfaD mutant Z0401 (expressing truncated LOS containing only lipid A-KDO) shows no significant difference in cell morphology compared to the wild-type LNP14912, whereas the LOS-deficient lpxA mutant Z0204 exhibits outer membrane detachment and structural abnormalities^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 10149-14-1
Molecular Weight 238.19
Formula C₈H₁₄O₈
SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CC(C(O)=O)=O
Synonyms

3-Deoxy-D-manno-2-octulosonic acid
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Neszmélyi A, Kosma P, Christian R, Schulz G, Unger FM. Empirical 13C-n.m.r.-correlations between the Escherichia coli K 13 and LP 1092 capsular polysaccharides and model oligosaccharides containing D-ribose and 3-deoxy-D-manno-2-octulosonic acid. Carbohydr Res. 1985 Jun 15;139:13-22.

[2]. Zarantonelli ML, et al. Differential role of lipooligosaccharide of Neisseria meningitidis in virulence and inflammatory response during respiratory infection in mice. Infection and immunity. 2006 Oct;74(10):5506-12.

[3]. Assignee/Inventors (KR 10-2019-0129245 A). Composition comprising Nelumbo nucifera polysaccharide containing KDO, neutral sugar and uronic acid for immunomodulation. KR 10-2019-0129245 A

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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