Ossamycin
Ossamycin is a macrolide antibiotic. Ossamycin has anti-fungal effect, and it has weaker anti-Gram-positive bacterial effect. Ossamycin inhibits L cells, Epstein-Barr ascites cancer cells, KB cells, sarcoma-180 cells, L-1210 cells, HeLa cells in cell culture with IC50s (μg/mL) of 0.007, 0.008, 0.005, 0.008, 0.003, 0.005, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2057463-74-6
- Formula: C49H85NO14
- Molecular Weight:912.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 2057463-74-6
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Molecular Weight 912.20
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Formula C49H85NO14
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SMILES
CC[C@@H](O)C[C@@H]1O[C@]2(CCC1)O[C@@]3([H])C[C@]4([C@@](/C=C/CCCCC[C@@](O)([C@@H]([C@H]([C@@H]([C@H]([C@@H]([C@](O)(/C=C/C(O[C@@]([C@@H]3C)([H])C2)=O)C)O)C)O)O[C@@H]5O[C@H]([C@H](CC5)N(C)C)C)O)C)([H])CC(C)(O4)C)O
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Structure Classification
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Initial Source
Str. hygroscopicus, Var. ossamyceticus C 8158 (ATCC 15420)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
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Directly Induced Neuron Culture
Directly induced neuron culture converts somatic cells, most commonly fibroblasts, into induced neurons without passing through a pluripotent or neural progenitor stage; classic evidence shows that mouse fibroblasts can be converted by Ascl1, Brn2/Pou3f2, and Myt1l, human fibroblasts can be converted by defined neuronal transcription factors, and human fibroblasts can also be converted by miR-9/9-124 with neurogenic or subtype-specifying transcription factors. The readout is acquisition of neuronal identity and function, assessed by neuronal morphology, neuronal markers such as Tuj1/βIII-tubulin, MAP2, synapsin, and subtype markers when relevant, together with functional assays such as action-potential firing, synaptic activity, and electrophysiology.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ossamycin Related Classifications
HY-N14853 Related Classifications
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