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製品番号: HY-144745

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HSR1304

HSR1304 (Compound 5d) is a potent inhibitor of NFκB. The multifunctional transcription factor, nuclear factor-κB (NF-κB), is broadly involved in multiple human diseases, such as cancer and chronic inflammation. HSR1304 has the potential for the research of cancer diseases.

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CAS 番号: 2763363-08-0
分子式: C₂₄H₂₁ClN₂O₃
分子量:420.89

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

HSR1304 構造式

CAS 番号: 2763363-08-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NF-κB アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
ACHN	GI₅₀	1.977 μM Compound: 5d	Anticancer activity against human ACNH cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human ACNH cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]
HCT-15	GI₅₀	1.739 μM Compound: 5d	Anticancer activity against human HCT-15 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human HCT-15 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]
MDA-MB-231	GI₅₀	2.281 μM Compound: 5d	Anticancer activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]
NCI-H23	GI₅₀	1.938 μM Compound: 5d	Anticancer activity against human NCI-H23 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human NCI-H23 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]
NUGC-3	GI₅₀	1.591 μM Compound: 5d	Anticancer activity against human NUCC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human NUCC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]
PC-3	GI₅₀	2.008 μM Compound: 5d	Anticancer activity against human PC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human PC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]

化学情報

CAS 番号 2763363-08-0
分子量 420.89
分子式 C₂₄H₂₁ClN₂O₃
SMILES

COC1=CC=CC=C1NC(C2C3=CC=CC=C3CCN2C(C4=CC=C(C=C4)Cl)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sim S, et al. Design, synthesis, and biological evaluation of potent 1,2,3,4-tetrahydroisoquinoline derivatives as anticancer agents targeting NF-κB signaling pathway. Bioorg Med Chem. 2021 Sep 15;46:116371. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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化学情報
純度とドキュメンテーション
参考文献

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HSR1304

NF-κB アイソフォーム固有の製品をすべて表示