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Cat. No.: HY-144745

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HSR1304

HSR1304 (Compound 5d) is a potent inhibitor of NFκB. The multifunctional transcription factor, nuclear factor-κB (NF-κB), is broadly involved in multiple human diseases, such as cancer and chronic inflammation. HSR1304 has the potential for the research of cancer diseases.

For research use only. We do not sell to patients.

CAS No.: 2763363-08-0
Formula: C₂₄H₂₁ClN₂O₃
Molecular Weight:420.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

HSR1304 Chemical Structure

CAS No.: 2763363-08-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
ACHN	GI₅₀	1.977 μM Compound: 5d	Anticancer activity against human ACNH cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human ACNH cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]
HCT-15	GI₅₀	1.739 μM Compound: 5d	Anticancer activity against human HCT-15 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human HCT-15 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]
MDA-MB-231	GI₅₀	2.281 μM Compound: 5d	Anticancer activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]
NCI-H23	GI₅₀	1.938 μM Compound: 5d	Anticancer activity against human NCI-H23 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human NCI-H23 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]
NUGC-3	GI₅₀	1.591 μM Compound: 5d	Anticancer activity against human NUCC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human NUCC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]
PC-3	GI₅₀	2.008 μM Compound: 5d	Anticancer activity against human PC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method Anticancer activity against human PC-3 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B method	[PMID: 34500188]

Chemical Information

CAS No. 2763363-08-0
Molecular Weight 420.89
Formula C₂₄H₂₁ClN₂O₃
SMILES

COC1=CC=CC=C1NC(C2C3=CC=CC=C3CCN2C(C4=CC=C(C=C4)Cl)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sim S, et al. Design, synthesis, and biological evaluation of potent 1,2,3,4-tetrahydroisoquinoline derivatives as anticancer agents targeting NF-κB signaling pathway. Bioorg Med Chem. 2021 Sep 15;46:116371. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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HSR1304

All NF-κB Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HSR1304 Related Classifications

HY-144745 Related Classifications