country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N21565

Copy Link Print Information

Euphomilone A

Euphomilone A is an ent-abietane-type diterpenoid osteoclastogenesis inhibitor and RANK inhibitor, found in the aerial parts of Euphorbia milii, possessing a 7/5/6 tricyclic system. Euphomilone A inhibits RANKL-induced osteoclastogenesis in monocyte/macrophage lineage cells. Euphomilone A can be used in research on bone resorption-related diseases.

For research use only. We do not sell to patients.

CAS No.: 2077182-79-5
Formula: C₂₀H₃₂O₃
Molecular Weight:320.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Euphomilone A Chemical Structure

CAS No.: 2077182-79-5

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC50	12.6 μM	Inhibition of RANKL-induced osteoclast formation in RAW 264.7 cells. Inhibition of RANKL-induced osteoclast formation in RAW 264.7 cells.	acs.orglett.6b03142

In Vitro

Euphomilone A inhibits RANKL-induced osteoclast formation in RAW 264.7 cells with an IC₅₀ of 12.6 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2077182-79-5
Molecular Weight 320.47
Formula C₂₀H₃₂O₃
SMILES

C[C@@]12[C@@]3([C@@](C(C(C)([C@@H](CC3)O)C)=O)([H])C[C@@]1([H])C[C@](C)(CC2)C=C)O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu S N, Huang D, Morris-Natschke S L, et al. Euphomilones A and B, ent-rosane diterpenoids with 7/5/6 and 5/7/6 skeletons from Euphorbia milii[J]. Organic letters, 2016, 18(23): 6132-6135.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote