Hydroxylated sclerosporin derivatives from the marine-derived fungus Cadophora malorum

  • J Nat Prod. 2010 Mar 26;73(3):476-8. doi: 10.1021/np900608d.
Celso Almeida  1 ,  Ekaterina Eguereva ,  Stefan Kehraus ,  Carsten Siering ,  Gabriele M König
Affiliations
  • 1. Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
PMID: 20052971 DOI: 10.1021/np900608d
Abstract

The marine-derived fungus Cadophora malorum was isolated from the green alga Enteromorpha sp. Growth on a biomalt medium supplemented with sea salt yielded an extract, from which we have isolated sclerosporin and four new hydroxylated sclerosporin derivatives, namely, 15-hydroxysclerosporin (2), 12-hydroxysclerosporin (3), 11-hydroxysclerosporin (4), and 8-hydroxysclerosporin (5). The compounds were evaluated in various biological activity assays. Compound 5 showed a weak fat-accumulation inhibitory activity against 3T3-L1 murine adipocytes.

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