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Cat. No.: HY-162970

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XD23

XD23 is a potent osteosarcoma inhibitor that works by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.

For research use only. We do not sell to patients.

CAS No.: 2806007-82-7
Formula: C₂₂H₂₆ClN₇O₃
Molecular Weight:471.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

XD23 Chemical Structure

CAS No.: 2806007-82-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

XD23 is a potent osteosarcoma inhibitor that works by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.

All Wnt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	5.2 μM Compound: 14m	Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay	[PMID: 35797896]
MCF7	IC₅₀	3.15 μM Compound: 14m	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay	[PMID: 35797896]
SK-HEP1	IC₅₀	2.04 μM Compound: 14m	Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay	[PMID: 35797896]
SK-MEL-2	IC₅₀	4.79 μM Compound: 14m	Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay	[PMID: 35797896]

Chemical Information

CAS No. 2806007-82-7
Molecular Weight 471.94
Formula C₂₂H₂₆ClN₇O₃
SMILES

ClC1=CC=CC(NC(CNC2=CC(N3CCN(C)CC3)=NC(N(C)C(N4C)=O)=C2C4=O)=O)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. https://www.cell.com/iscience/fulltext/S2589-0042(24)01983-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004224019837%3Fshowall%3Dtrue

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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XD23

All Wnt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

XD23 Related Classifications

HY-162970 Related Classifications