Idasanutlin (enantiomer)
Based on 1 Customer Validation
Idasanutlin enantiomer is the isomer of Idasanutlin (HY-15676), and can be used as an experimental control. Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM.
For research use only. We do not sell to patients.
- Purity: 99.18%
- Formula: C31H29Cl2F2N3O4
- Molecular Weight:616.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 616.48
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Formula C31H29Cl2F2N3O4
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Color White to off-white
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SMILES
O=C([C@H]1N[C@H](CC(C)(C)C)[C@](C2=CC=C(Cl)C=C2F)(C#N)[C@@H]1C3=CC=CC(Cl)=C3F)NC4=C(OC)C=C(C(O)=O)C=C4
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Synonyms
RG7388 (enantiomer)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (162.21 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ding Q, et al. Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development. J Med Chem. 2013 Jul 25;56(14):5979-83. [Content Brief]
[2]. Higgins B, et al. Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach. Clin Cancer Res. 2014, 20(14), 3742-3752. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6221 mL | 8.1106 mL | 16.2211 mL | 40.5528 mL |
| 5 mM | 0.3244 mL | 1.6221 mL | 3.2442 mL | 8.1106 mL | |
| 10 mM | 0.1622 mL | 0.8111 mL | 1.6221 mL | 4.0553 mL | |
| 15 mM | 0.1081 mL | 0.5407 mL | 1.0814 mL | 2.7035 mL | |
| 20 mM | 0.0811 mL | 0.4055 mL | 0.8111 mL | 2.0276 mL | |
| 25 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6221 mL | |
| 30 mM | 0.0541 mL | 0.2704 mL | 0.5407 mL | 1.3518 mL | |
| 40 mM | 0.0406 mL | 0.2028 mL | 0.4055 mL | 1.0138 mL | |
| 50 mM | 0.0324 mL | 0.1622 mL | 0.3244 mL | 0.8111 mL | |
| 60 mM | 0.0270 mL | 0.1352 mL | 0.2704 mL | 0.6759 mL | |
| 80 mM | 0.0203 mL | 0.1014 mL | 0.2028 mL | 0.5069 mL | |
| 100 mM | 0.0162 mL | 0.0811 mL | 0.1622 mL | 0.4055 mL |
Idasanutlin (enantiomer) Related Classifications
HY-15676A Related Classifications
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