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Cat. No.: HY-146002

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IDH2R140Q-IN-1

IDH2R140Q-IN-1 (compound C6) is a potent inhibitor of IDH2^R140Q, with an IC₅₀ of 6.1 nM. IDH2R140Q-IN-1 can be used for the research of acute myeloid leukemia.

For research use only. We do not sell to patients.

CAS No.: 2469044-23-1
Formula: C₂₂H₂₀F₆N₆
Molecular Weight:482.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

IDH2R140Q-IN-1 Chemical Structure

CAS No.: 2469044-23-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IDH2R140Q-IN-1 (compound C6) is a potent inhibitor of IDH2^R140Q, with an IC₅₀ of 6.1 nM. IDH2R140Q-IN-1 can be used for the research of acute myeloid leukemia^[1].

All Isocitrate Dehydrogenase (IDH) Isoforms :

IDH1
IDH2

Cellular Effect

Cell Line	Type	Value	Description	References
TF-1	IC₅₀	>10 μM Compound: C6	Cytotoxicity aganist human TF-1 cells harboring IDH2 mutant Cytotoxicity aganist human TF-1 cells harboring IDH2 mutant	[PMID: 32679449]

Chemical Information

CAS No. 2469044-23-1
Molecular Weight 482.42
Formula C₂₂H₂₀F₆N₆
SMILES

FC(C1=CC=CC(C2=NC(NCCCCCC3)=NC(NC4=CC3=CC(C(F)(F)F)=C4)=N2)=N1)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Che J, et, al. Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells. Eur J Med Chem. 2020 Oct 1;203:112491. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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