Lu AA33810
Based on 1 Customer Validation
Lu AA33810 is a selective, orally active and brain-penetrant antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the rat receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects.
For research use only. We do not sell to patients.
- Purity: 98.3%
- CAS No.: 304008-29-5
- Formula: C19H25N3O2S3
- Molecular Weight:423.62
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Orally Active Compound Library
HY-L061
-
Neurotransmitter Receptor Compound Library
HY-L062
-
Anti-Obesity Compound Library
HY-L087
-
Antidepressant Compound Library
HY-L108
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Highly Selective Inhibitors Library
HY-L158
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
-
GPCR/G Protein Compound Library
HY-L006
-
Neuronal Signaling Compound Library
HY-L013
-
CNS-Penetrant Compound Library
HY-L028
All Neuropeptide Y Receptor Isoforms
More
Biological Activity
|
hY5 receptor 1.5 nM (Ki) |
Lu AA33810 antagonizes NPY-evoked cAMP and calcium mobilization in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Flinders sensitive line rats, chronic dosing of Lu AA33810 (10 mg/kg/day i.p.) produces anxiolytic-like effects in the social interaction test, plus antidepressant-like effects in the forced swim test[1].
In Wistar rats exposed to chronic mild stress, chronic dosing of Lu AA33810 (3 and 10 mg/kg/day i.p.) produces antidepressant-like activity, i.e., normalization of stress-induced decrease in sucrose consumption[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 304008-29-5
-
Appearance Solid
-
Molecular Weight 423.62
-
Formula C19H25N3O2S3
-
Color White to off-white
-
SMILES
CS(NC[C@@H](CC1)CC[C@H]1NC2=NC3=C(S2)CCSC4=CC=CC=C34)(=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 42.36 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Walker MW, et al. The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. J Pharmacol Exp Ther. 2009 Mar;328(3):900-11. [Content Brief]
[2]. Domin H,et al. Antidepressant-like activity of the neuropeptide Y Y5 receptor antagonist Lu AA33810: behavioral, molecular, and immunohistochemical evidence. Psychopharmacology (Berl). 2017 Feb;234(4):631-645. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3606 mL | 11.8030 mL | 23.6061 mL | 59.0152 mL |
| 5 mM | 0.4721 mL | 2.3606 mL | 4.7212 mL | 11.8030 mL | |
| 10 mM | 0.2361 mL | 1.1803 mL | 2.3606 mL | 5.9015 mL | |
| 15 mM | 0.1574 mL | 0.7869 mL | 1.5737 mL | 3.9343 mL | |
| 20 mM | 0.1180 mL | 0.5902 mL | 1.1803 mL | 2.9508 mL | |
| 25 mM | 0.0944 mL | 0.4721 mL | 0.9442 mL | 2.3606 mL | |
| 30 mM | 0.0787 mL | 0.3934 mL | 0.7869 mL | 1.9672 mL | |
| 40 mM | 0.0590 mL | 0.2951 mL | 0.5902 mL | 1.4754 mL | |
| 50 mM | 0.0472 mL | 0.2361 mL | 0.4721 mL | 1.1803 mL | |
| 60 mM | 0.0393 mL | 0.1967 mL | 0.3934 mL | 0.9836 mL | |
| 80 mM | 0.0295 mL | 0.1475 mL | 0.2951 mL | 0.7377 mL |
Lu AA33810 Related Classifications
HY-107729 Related Classifications
Powered by Bioz