PH-002-d8
Based on 1 Customer Validation
PH-002-d8 is the deuterium labeled PH-002 (HY-112798). PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.
For research use only. We do not sell to patients.
- Formula: C27H25D8N5O4
- Molecular Weight:499.63
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 1311174-68-1
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Appearance Solid
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Molecular Weight 499.63
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Formula C27H25D8N5O4
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SMILES
O=C1N(C)N=C(CC(NC2=CC=C(CN3C([2H])([2H])C([2H])([2H])N(C(OC(C)(C)C)=O)C([2H])([2H])C3([2H])[2H])C=C2)=O)C4=CC=CC=C41
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (200.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0015 mL | 10.0074 mL | 20.0148 mL | 50.0370 mL |
| 5 mM | 0.4003 mL | 2.0015 mL | 4.0030 mL | 10.0074 mL | |
| 10 mM | 0.2001 mL | 1.0007 mL | 2.0015 mL | 5.0037 mL | |
| 15 mM | 0.1334 mL | 0.6672 mL | 1.3343 mL | 3.3358 mL | |
| 20 mM | 0.1001 mL | 0.5004 mL | 1.0007 mL | 2.5019 mL | |
| 25 mM | 0.0801 mL | 0.4003 mL | 0.8006 mL | 2.0015 mL | |
| 30 mM | 0.0667 mL | 0.3336 mL | 0.6672 mL | 1.6679 mL | |
| 40 mM | 0.0500 mL | 0.2502 mL | 0.5004 mL | 1.2509 mL | |
| 50 mM | 0.0400 mL | 0.2001 mL | 0.4003 mL | 1.0007 mL | |
| 60 mM | 0.0334 mL | 0.1668 mL | 0.3336 mL | 0.8340 mL | |
| 80 mM | 0.0250 mL | 0.1251 mL | 0.2502 mL | 0.6255 mL | |
| 100 mM | 0.0200 mL | 0.1001 mL | 0.2001 mL | 0.5004 mL |
PH-002-d8 Related Classifications
HY-112798S Related Classifications
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