Tremor Models

Oxotremorine sesquifumarate is a potent muscarinic acetylcholine receptor (mAChR) agonist capable of crossing the blood-brain barrier. Oxotremorine sesquifumarate specifically binds to and activates mAChR, mediating synaptic transmission, influencing the survival and differentiation of nerve cells, and inducing symptoms associated with cholinergic overactivation in animals. Oxotremorine sesquifumarate can be used as a pharmacological agent to induce symptoms such as tremors, hypothermia, and salivation in experimental animals. Oxotremorine sesquifumarate is utilized in research on neurological disorders, including Parkinson’s disease and depression.

Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals.

Oxotremorine is a potent muscarinic acetylcholine receptor (mAChR) agonist capable of crossing the blood-brain barrier. Oxotremorine specifically binds to and activates mAChR, mediating synaptic transmission, influencing the survival and differentiation of nerve cells, and inducing symptoms associated with cholinergic overactivation in animals. Oxotremorine can be used as a pharmacological agent to induce symptoms such as tremors, hypothermia, and salivation in experimental animals. Oxotremorine is utilized in research on neurological disorders, including Parkinson’s disease and depression.