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Cat. No.: HY-123592

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INK4C-IN-3

INK4C-IN-3 is a synthetic coumarin amide compound and a small-molecule inhibitor of INK4C (p18INK4C). INK4C-IN-3 promotes the ex vivo expansion of human and mouse hematopoietic stem cells. INK4C-IN-3 can be used in research related to hematopoietic stem cell expansion.

For research use only. We do not sell to patients.

CAS No.: 1111287-26-3
Formula: C₁₉H₁₆N₂O₄
Molecular Weight:336.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

INK4C-IN-3 Chemical Structure

CAS No.: 1111287-26-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

INK4C-IN-3 (compound 41) (administered continuously for 14 days) potently promotes the expansion of murine C57BL/6 CD34⁻LKS hematopoietic stem cells in vitro, with an ED₅₀ of 9.92 nM^[2].
INK4C-IN-3 (0.01-1 μM; 7 days) promotes the ex vivo expansion of human umbilical cord blood CD34⁺ hematopoietic stem cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Cell Viability Assay^[2]

View Protocol

Cell Line:

human umbilical cord blood CD34+ hematopoietic stem cells
Concentration:

0.01, 0.1, 1 μM
Incubation Time:

7 days
Result:

Promoted the ex vivo expansion of human umbilical cord blood CD34⁺ hematopoietic stem cells.

Chemical Information

CAS No. 1111287-26-3
Molecular Weight 336.34
Formula C₁₉H₁₆N₂O₄
SMILES

O=C(C1=CC=C(C=C1)NC(C)=O)NC2=CC(OC3=O)=C(C(C)=C3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ronad PM, et al. Synthesis and evaluation of anti-inflammatory and analgesic activities of a novel series of substituted-N-(4-methyl-2-oxo-2H-chromen-7-yl) benzamides. Arzneimittelforschung. 2008;58(12):641-6. [Content Brief]

[2]. Xie XQ, et al. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Scientific reports. 2015 Dec 18;5:18115. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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