country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-123592

Copy Link Print Information

INK4C-IN-3

INK4C-IN-3 is a synthetic coumarin amide compound and a small-molecule inhibitor of INK4C (p18INK4C). INK4C-IN-3 promotes the ex vivo expansion of human and mouse hematopoietic stem cells. INK4C-IN-3 can be used in research related to hematopoietic stem cell expansion.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1111287-26-3
Formel: C₁₉H₁₆N₂O₄
Molecular Weight:336.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

INK4C-IN-3 Chemical Structure

CAS. Nr.: 1111287-26-3

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

INK4C-IN-3 (compound 41) (administered continuously for 14 days) potently promotes the expansion of murine C57BL/6 CD34⁻LKS hematopoietic stem cells in vitro, with an ED₅₀ of 9.92 nM^[2].
INK4C-IN-3 (0.01-1 μM; 7 days) promotes the ex vivo expansion of human umbilical cord blood CD34⁺ hematopoietic stem cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

human umbilical cord blood CD34+ hematopoietic stem cells
Concentration:

0.01, 0.1, 1 μM
Incubation Time:

7 days
Result:

Promoted the ex vivo expansion of human umbilical cord blood CD34⁺ hematopoietic stem cells.

Chemical Information

CAS. Nr. 1111287-26-3
Molecular Weight 336.34
Formel C₁₉H₁₆N₂O₄
SMILES

O=C(C1=CC=C(C=C1)NC(C)=O)NC2=CC(OC3=O)=C(C(C)=C3)C=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ronad PM, et al. Synthesis and evaluation of anti-inflammatory and analgesic activities of a novel series of substituted-N-(4-methyl-2-oxo-2H-chromen-7-yl) benzamides. Arzneimittelforschung. 2008;58(12):641-6. [Content Brief]

[2]. Xie XQ, et al. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Scientific reports. 2015 Dec 18;5:18115. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen