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  4. Inositol nicotinate

Inositol nicotinate  (Synonyms: Inositol niacinate; Hexanicit)

Cat. No.: HY-122365 Purity: 98.05%
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Inositol nicotinate (Hexanicit) has vasodilating effects and can be used in research on peripheral arterial disease, showing efficacy when taken orally. Inositol nicotinate does not significantly improve triglyceride levels in mice induced by biphenyl esters.

For research use only. We do not sell to patients.

Inositol nicotinate

Inositol nicotinate Chemical Structure

CAS No. : 6556-11-2

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Based on 1 publication(s) in Google Scholar

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Inositol nicotinate Related Antibodies

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Description

Inositol nicotinate (Hexanicit) has vasodilating effects and can be used in research on peripheral arterial disease, showing efficacy when taken orally. Inositol nicotinate does not significantly improve triglyceride levels in mice induced by biphenyl esters[1][2].

In Vivo

Inositol nicotinate (0.1-0.3 g/kg, oral , once a day, four days) shows no significant improvement in biphenyl ester-induced hypertriglyceridemia in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bifendate-treated mice[1]
Dosage: 0.1, 0.3 g/kg; daily; 4 days
Administration: Oral
Result: Reduced the level of serum TG slightly, but the difference was not statistically significant.
Molecular Weight

810.72

Formula

C42H30N6O12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CN=C1)O[C@H]2[C@@H](OC(C3=CC=CN=C3)=O)[C@@H](OC(C4=CC=CN=C4)=O)[C@H](OC(C5=CC=CN=C5)=O)[C@@H](OC(C6=CC=CN=C6)=O)[C@@H]2OC(C7=CC=CN=C7)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

5% TFA in Water : 25 mg/mL (30.84 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2335 mL 6.1674 mL 12.3347 mL
5 mM 0.2467 mL 1.2335 mL 2.4669 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
5% TFA in Water 1 mM 1.2335 mL 6.1674 mL 12.3347 mL 30.8368 mL
5 mM 0.2467 mL 1.2335 mL 2.4669 mL 6.1674 mL
10 mM 0.1233 mL 0.6167 mL 1.2335 mL 3.0837 mL
15 mM 0.0822 mL 0.4112 mL 0.8223 mL 2.0558 mL
20 mM 0.0617 mL 0.3084 mL 0.6167 mL 1.5418 mL
25 mM 0.0493 mL 0.2467 mL 0.4934 mL 1.2335 mL
30 mM 0.0411 mL 0.2056 mL 0.4112 mL 1.0279 mL
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Inositol nicotinate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inositol nicotinate6556-11-2Inositol niacinate HexanicitDrug DerivativeDrug derivativeRaynaud's phenomenaintermittent claudicationInhibitorinhibitorinhibit

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