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Cat. No.: HY-P4062

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Insulin peglispro

Name: Insulin peglispro
Brand: MedChemExpress
SKU: HY-P4062
Availability: PreOrder

(Synonyms: BIL)

Insulin peglispro (BIL) is a basal insulin with a flat, prolonged activity profile. Insulin peglispro can exhibit better glycaemic control compared to conventional insulins.

For research use only. We do not sell to patients.

CAS No.: 1200440-65-8
Formula: C₃₇₀H₅₆₆N₁₀₄O₁₁₀S₄
Molecular Weight:8359.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Insulin peglispro Chemical Structure

CAS No.: 1200440-65-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
- Clinical Trial
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Insulin peglispro (BIL) is a basal insulin with a flat, prolonged activity profile. Insulin peglispro can exhibit better glycaemic control compared to conventional insulins^[1].

In Vivo

Insulin peglispro (BIL) (s.c., 17, 0.45 or 1.15 mg/kg/d, 52 week) has no effect on Crl:CD(SD) rat survival at any dose, resulting in some increase in body weight. Serum glucose concentrations are unaffected at an administered dose of 0.17 mg/kg, while 0.45 mg/kg shows lower serum glucose concentrations at 3 and 6 hours post-dose on day 1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1200440-65-8
Molecular Weight 8359.32
Formula C₃₇₀H₅₆₆N₁₀₄O₁₁₀S₄
Synonyms

BIL
Sequence

Chain1:Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Lys-Pro-Thrchain 2：Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn(Disulfide chain 1 cys7-chain 2 cys7, Disulfide chain 1 cys19-chain 2 cys20, Disulfide chain 2 cys6-cys11)
Sequence Shortening

Chain1:FVNQHLCGSHLVEALYLVCGERGFFYTKPTChain2:GIVEQCCTSICSLYQLENYCN(Disulfide chain 1 cys7-chain 2 cys7, Disulfide chain 1 cys19-chain 2 cys20, Disulfide chain 2 cys6-cys11)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Signal Pathway Related

Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Richard A Byrd, et al. Chronic Toxicology Studies of Basal Insulin Peglispro in Rats and Dogs: A Novel, PEGylated Insulin Lispro Analog with a Prolonged Duration of Action. Toxicol Pathol. 2017 Apr;45(3):402-415. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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