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  2. iRGD peptide 1 TFA

iRGD peptide 1 TFA 

Cat. No.: HY-P0122B
Handling Instructions

iRGD peptide 1 TFA is the prototypic tumor-specific tissue-penetrating peptide, which delivers drugs deep into extravascular tumor tissue. iRGD peptide 1 TFA has anti-metastatic activity.

For research use only. We do not sell to patients.

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iRGD peptide 1 TFA Chemical Structure

iRGD peptide 1 TFA Chemical Structure

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Description

iRGD peptide 1 TFA is the prototypic tumor-specific tissue-penetrating peptide, which delivers drugs deep into extravascular tumor tissue. iRGD peptide 1 TFA has anti-metastatic activity[1].

In Vitro

iRGD peptide 1 (iRGD) inhibits migration of tumor cells and caused chemorepulsion in vitro in a CendR- and NRP-1-dependent manner. iRGD peptide 1 induces dramatic collapse of cellular processes and partial cell detachment, resulting in the repellent activity. These effects are prominently displayed when the cells are seeded on fibronectin, suggesting a role of CendR in functional regulation of integrins[1].

In Vivo

iRGD peptide 1 (amino acid sequence: CRGDKGPDC; 4 μmol/kg; intravenous injection; every other day; for 21 days) potently inhibits spontaneous metastasis in mice[1].

Molecular Weight

1064.08

Formula

C₃₇H₆₀F₃N₁₃O₁₆S₂

Sequence

{Cys}{Arg}{Gly}{Asp}{Lys}{Gly}{Pro}{Asp}{Cys}

Sequence Shortening

CRGDKGPDC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

iRGD peptide 1iRGD peptide1iRGD peptide-1OthersCRGDKGPDCtumor-penetratingpeptideanti-metastaticCendRNRP-1prototypicInhibitorinhibitorinhibit

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iRGD peptide 1 TFA
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HY-P0122B
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