2. Peptides
  3. iRGD peptide 1 TFA

iRGD peptide 1 TFA is the prototypic tumor-specific tissue-penetrating peptide, which delivers agents deep into extravascular tumor tissue. iRGD peptide 1 TFA has anti-metastatic activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

iRGD peptide 1 TFA Chemical Structure

iRGD peptide 1 TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 60 In-stock
5 mg USD 150 In-stock
10 mg USD 240 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

iRGD peptide 1 TFA Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

iRGD peptide 1 TFA is the prototypic tumor-specific tissue-penetrating peptide, which delivers agents deep into extravascular tumor tissue. iRGD peptide 1 TFA has anti-metastatic activity[1].

In Vitro

iRGD peptide 1 (iRGD) inhibits migration of tumor cells and caused chemorepulsion in vitro in a CendR- and NRP-1-dependent manner. iRGD peptide 1 induces dramatic collapse of cellular processes and partial cell detachment, resulting in the repellent activity. These effects are prominently displayed when the cells are seeded on fibronectin, suggesting a role of CendR in functional regulation of integrins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

iRGD peptide 1 TFA Related Antibodies
In Vivo

iRGD peptide 1 (amino acid sequence: CRGDKGPDC; 4 μmol/kg; intravenous injection; every other day; for 21 days) potently inhibits spontaneous metastasis in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1064.08

Formula

C37H60F3N13O16S2
Appearance

Solid

Color

White to off-white

Sequence

Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys
Sequence Shortening

CRGDKGPDC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (93.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9398 mL 4.6989 mL 9.3978 mL
5 mM 0.1880 mL 0.9398 mL 1.8796 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9398 mL 4.6989 mL 9.3978 mL 23.4945 mL
5 mM 0.1880 mL 0.9398 mL 1.8796 mL 4.6989 mL
10 mM 0.0940 mL 0.4699 mL 0.9398 mL 2.3494 mL
15 mM 0.0627 mL 0.3133 mL 0.6265 mL 1.5663 mL
20 mM 0.0470 mL 0.2349 mL 0.4699 mL 1.1747 mL
25 mM 0.0376 mL 0.1880 mL 0.3759 mL 0.9398 mL
30 mM 0.0313 mL 0.1566 mL 0.3133 mL 0.7831 mL
40 mM 0.0235 mL 0.1175 mL 0.2349 mL 0.5874 mL
50 mM 0.0188 mL 0.0940 mL 0.1880 mL 0.4699 mL
60 mM 0.0157 mL 0.0783 mL 0.1566 mL 0.3916 mL
80 mM 0.0117 mL 0.0587 mL 0.1175 mL 0.2937 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iRGD peptide 1iRGD peptide1iRGD peptide-1OthersCRGDKGPDCtumor-penetratingpeptideanti-metastaticCendRNRP-1prototypicInhibitorinhibitorinhibit

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iRGD peptide 1 TFA
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