Dendrogenin A
Based on 1 Customer Validation
Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC50 of 4.1 and 6.2 µM. Dendrogenin A arrests the cell cycle at G0/G1 phase.
For research use only. We do not sell to patients.
- Purity: 96.7%
- CAS No.: 1191043-85-2
- Formula: C32H55N3O2
- Molecular Weight:513.80
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.56 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human A549 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human A549 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| B16-F10 | IC50 |
0.68 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against mouse B16F10 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse B16F10 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| HCT-8 | IC50 |
0.89 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human HCT8 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human HCT8 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| KG-1 | IC50 |
5.53 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human KG1 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human KG1 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| MCF7 | IC50 |
2.31 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human MCF7 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human MCF7 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| N2a | IC50 |
2.32 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against mouse Neuro2a cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse Neuro2a cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| NB-4 | IC50 |
1.32 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human NB4 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human NB4 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| P19 | IC50 |
1.8 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against mouse P19 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse P19 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| P19 | IC50 |
2.4 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against mouse P19 cells after 3 days by trypan blue exclusion assay
Cytotoxicity against mouse P19 cells after 3 days by trypan blue exclusion assay
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[PMID: 19821610] |
| SH-SY5Y | IC50 |
1.35 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human SH-SY5Y cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SH-SY5Y cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| SK-MEL-28 | IC50 |
2.12 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human SK-MEL-28 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| SK-N-SH | IC50 |
2.24 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human SK-N-SH cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SK-N-SH cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| SW-620 | IC50 |
0.42 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human SW620 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human SW620 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| TS/A | IC50 |
1.28 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against mouse TSA cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against mouse TSA cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| U-87MG ATCC | IC50 |
0.74 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human U87 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human U87 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| U-937 | IC50 |
0.79 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human U937 cells after 72 hrs by trypan blue exclusion assay
Cytotoxicity against human U937 cells after 72 hrs by trypan blue exclusion assay
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[PMID: 19821610] |
| U-937 | IC50 |
0.8 μM
Compound: 14, Dendrogenin A
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Cytotoxicity against human U937 cells after 3 days by trypan blue exclusion assay
Cytotoxicity against human U937 cells after 3 days by trypan blue exclusion assay
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[PMID: 19821610] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1191043-85-2
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Appearance Solid
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Molecular Weight 513.80
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Formula C32H55N3O2
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@](C[C@H]([C@]1(C[C@H](CC2)O)O)NCCC4=CN=CN4)([H])[C@@]5([H])[C@](CC3)([C@@](CC5)([H])[C@H](C)CCCC(C)C)C
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Synonyms
DDA
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 30 mg/mL (58.39 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9463 mL | 9.7314 mL | 19.4628 mL | 48.6571 mL |
| 5 mM | 0.3893 mL | 1.9463 mL | 3.8926 mL | 9.7314 mL | |
| 10 mM | 0.1946 mL | 0.9731 mL | 1.9463 mL | 4.8657 mL | |
| 15 mM | 0.1298 mL | 0.6488 mL | 1.2975 mL | 3.2438 mL | |
| 20 mM | 0.0973 mL | 0.4866 mL | 0.9731 mL | 2.4329 mL | |
| 25 mM | 0.0779 mL | 0.3893 mL | 0.7785 mL | 1.9463 mL | |
| 30 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6219 mL | |
| 40 mM | 0.0487 mL | 0.2433 mL | 0.4866 mL | 1.2164 mL | |
| 50 mM | 0.0389 mL | 0.1946 mL | 0.3893 mL | 0.9731 mL |
Dendrogenin A Related Classifications
HY-149132 Related Classifications
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