Fcgr2a - Fc gamma receptor 2A Gene

Also Known as Fcgr3; Fcgr3a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116591

Summary

Enables immunoglobulin receptor binding activity. Involved in several processes, including regulation of Fc-gamma Receptor signaling pathway involved in phagocytosis; regulation of antibody-dependent cellular cytotoxicity; and regulation of tumor necrosis factor production. Located in cell surface. Used to study crescentic glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic Cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to human FCGR2A (Fc fragment of IgG receptor IIa). [provided by Alliance of Genome Resources, Apr 2022]

Fcgr2a Products (1)

mRNA Protein Name
NM_053843.3 NP_446295.2 low affinity immunoglobulin gamma Fc region receptor III

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables immunoglobulin receptor binding IDA
IDA: Inferred from direct assay
22184119 RGD
Biological Process GO Annotation Evidence References Source
involved in nerve development IEP
IEP: Inferred from expression pattern
1533683 RGD
involved in regulation of Fc receptor mediated stimulatory signaling pathway IMP
IMP: Inferred from mutant phenotype
16482158 RGD
involved in regulation of antibody-dependent cellular cytotoxicity IMP
IMP: Inferred from mutant phenotype
16482158 RGD
involved in regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
16482158 RGD
involved in regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
22184119 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
22184119 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low affinity immunoglobulin gamma Fc region receptor III

  • Fc fragment of IgG low affinity IIa receptor for (CD32)

  • Fc fragment of IgG receptor IIa

  • Fc fragment of IgG, low affinity IIa, receptor (CD32)

  • Fc gamma receptor IIa

  • Fc receptor, IgG, low affinity III

  • fc-gamma RIII

  • fcRIII

  • igG Fc receptor III

Recombinant Fcgr2a Proteins

Cat. No. Product Name Accession Purity
HY-P76233 Fc gamma RIIA/CD32a Protein, Rat (HEK293, Fc) A0A8L2Q236/NP_446295 (D32-L216) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990676 VIB-9600 Inhibitor 99.41% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04828 FCGR2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17922 Fcgr2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23733 Fcgr2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fcgr2a NCBI NCBI:2212