TNPO2 - transportin 2 Gene

Also Known as IPO3; TRN2; KPNB2B; IDDHISD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 30000

About TNPO2

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,699,201-12,723,932 (from NCBI)

This gene has 18 transcripts (splice variants), 189 orthologues, 5 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 25.6), testis (RPKM 20.6) and 25 other tissues.

Summary

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within negative regulation of muscle cell differentiation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TNPO2 Products (11)

mRNA Protein Name
NM_001136195.2 NP_001129667.1 transportin-2 isoform 2
NM_001136196.2 NP_001129668.1 transportin-2 isoform 1
NM_001382236.1 NP_001369165.1 transportin-2 isoform 2
NM_001382237.1 NP_001369166.1 transportin-2 isoform 2
NM_001382238.1 NP_001369167.1 transportin-2 isoform 2
NM_001382239.1 NP_001369168.1 transportin-2 isoform 2
NM_001382240.1 NP_001369169.1 transportin-2 isoform 1
NM_001382241.1 NP_001369170.1 transportin-2 isoform 1
NM_001382242.1 NP_001369171.1 transportin-2 isoform 1
NM_001382243.1 NP_001369172.1 transportin-2 isoform 3
NM_013433.5 NP_038461.2 transportin-2 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12896982 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNPO2 Protein Structure

IBN_N

IBN_N: Importin-beta N-terminal domain (32 - 98)

HEAT_EZ

HEAT_EZ: HEAT-like repeat (408 - 461)

HEAT

HEAT: HEAT repeat (665 - 695)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 897 a.a.
Protein Preferred Names Protein Names

transportin-2

  • importin 3

TNPO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNPO2 O14787 PNMA5 Homo sapiens Q96PV4
Y2H Prey Pooling
25416956
Intra
TNPO2 O14787 CAMK2D Homo sapiens Q13557
Y2H Prey Pooling
25416956
Intra
TNPO2 O14787 CAMK2D Homo sapiens Q13557
Y2H Array
31515488
Intra
TNPO2 O14787 APIP Homo sapiens Q96GX9
Y2H Array
25416956
Intra
TNPO2 O14787 APIP Homo sapiens Q96GX9
Y2H Array
31515488
Intra
TNPO2 O14787 APIP Homo sapiens Q96GX9
Validated Y2H
25416956
Intra
TNPO2 O14787 TERF1 Homo sapiens P54274
Pull Down
21044950
Intra
TNPO2 O14787 NME1 Homo sapiens P15531
Validated Y2H
25416956
Intra
TNPO2 O14787 NME1 Homo sapiens P15531
Y2H Prey Pooling
25416956
Intra
TNPO2 O14787 KLHL2 Homo sapiens O95198
Y2H Array
31515488
Intra
TNPO2 O14787 KLHL2 Homo sapiens O95198
Y2H Prey Pooling
25416956
Intra
TNPO2 O14787 KLHL2 Homo sapiens O95198
Validated Y2H
25416956
Intra
TNPO2 O14787 KLHL2 Homo sapiens O95198
Y2H Array
25416956
Intra
TNPO2 O14787 C1orf94 Homo sapiens Q6P1W5
Y2H Prey Pooling
25416956
Intra
TNPO2 O14787 C1orf94 Homo sapiens Q6P1W5
Y2H Array
25416956
Intra
TNPO2 O14787 EXOC5 Homo sapiens O00471
Y2H Prey Pooling
25416956
Intra
TNPO2 O14787 EXOC5 Homo sapiens O00471
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder With Hypotonia, Impaired Speech, And Dysmorphic Facies

  • IDDHISD
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14860 TNPO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TNPO2 VGNC VGNC:79216
Canis familiaris TNPO2 VGNC VGNC:47695
Rattus norvegicus TNPO2 RGD RGD:1310356
Felis catus TNPO2 VGNC VGNC:66431
Mus musculus TNPO2 MGD MGI:2384849
Bos taurus TNPO2 VGNC VGNC:36200
Others TNPO2 NCBI