HGF - hepatocyte growth factor Gene
Also Known as SF; HGFB; HPTA; F-TCF; DFNB39
Species: Homo sapiens
About HGF
This gene has 11 transcripts (splice variants), 291 orthologues, 5 paralogues and is associated with 2 phenotypes. Biased expression in placenta (RPKM 90.6), adrenal (RPKM 7.0) and 2 other tissues.
Summary
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
HGF Products (10)
| mRNA | Protein | Name |
|---|---|---|
| NM_000601.6 | NP_000592.3 | hepatocyte growth factor isoform 1 preproprotein |
| NM_001010931.3 | NP_001010931.1 | hepatocyte growth factor isoform 2 precursor |
| NM_001010932.3 | NP_001010932.1 | hepatocyte growth factor isoform 3 preproprotein |
| NM_001010933.3 | NP_001010933.1 | hepatocyte growth factor isoform 4 precursor |
| NM_001010934.3 | NP_001010934.1 | hepatocyte growth factor isoform 5 precursor |
| NM_000601.6 | NP_000592.3 | hepatocyte growth factor isoform 1 preproprotein |
| NM_001010931.3 | NP_001010931.1 | hepatocyte growth factor isoform 2 precursor |
| NM_001010932.3 | NP_001010932.1 | hepatocyte growth factor isoform 3 preproprotein |
| NM_001010933.3 | NP_001010933.1 | hepatocyte growth factor isoform 4 precursor |
| NM_001010934.3 | NP_001010934.1 | hepatocyte growth factor isoform 5 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables chemoattractant activity |
IDA
IDA: Inferred from direct assay
|
21245381 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
17804794 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
1846706 | GOA |
HGF Protein Structure
PAN_1: PAN domain (42 - 121)
Kringle: Kringle domain (128 - 206)
Kringle: Kringle domain (211 - 288)
Kringle: Kringle domain (305 - 383)
Kringle: Kringle domain (391 - 469)
Trypsin: Trypsin (501 - 716)
- 0
- 200
- 400
- 600
- 728 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
hepatocyte growth factor |
|
HGF Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
HGF | P14210 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 25416956 | |
|
Intra
|
HGF | P14210 | MET | Homo sapiens | P08581 | 15167892 | |
|
Intra
|
HGF | P14210 | MET | Homo sapiens | P08581 | 17804794 | |
|
Intra
|
HGF | P14210 | KBTBD7 | Homo sapiens | Q8WVZ9 | 33961781 | |
|
Intra
|
HGF | P14210 | MEOX2 | Homo sapiens | P50222 | 25416956 | |
|
Intra
|
HGF | P14210 | FKBP7 | Homo sapiens | Q9Y680 | 33961781 | |
|
Intra
|
HGF | P14210 | MEOX2 | Homo sapiens | P50222 | 25416956 | |
|
Intra
|
HGF | P14210 | HGF | Homo sapiens | P14210 | 17804794 | |
|
Intra
|
HGF | P14210 | HGFAC | Homo sapiens | Q04756 | 20004165 | |
|
Intra
|
HGF | P14210 | HGF | Homo sapiens | P14210 | 20624990 | |
|
Intra
|
HGF | P14210 | KBTBD6 | Homo sapiens | Q86V97 | 33961781 | |
|
Cross
|
HGF | P14210 | Met | Mus musculus | P16056 | 18585357 | |
|
Intra
|
HGF | P14210 | Hgf | Rattus norvegicus | P17945 | 11597998 |
Recombinant HGF Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7121 | HGF Protein, Human (CHO) | P14210-1 (Q32-S728) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70627 | HGF Protein, Human (HEK293, His) | P14210-1 (Q32-S728) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Deafness, Autosomal Recessive 39 |
|
|
| Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb |
|
|
| Obstructive Nephropathy |
|
|
| Liver Disease |
|
|
| Acute Liver Failure |
|
|
| Liver Cirrhosis |
|
|
| Microvascular Complications Of Diabetes 1 |
|
|
| Short Bowel Syndrome |
|
|
| Biliary Atresia |
|
|
| Gastric Ulcer |
|
|
| Alcoholic Hepatitis |
|
|
| Acute Kidney Tubular Necrosis |
|
|
| Salivary Gland Carcinoma |
|
|
| Arteriosclerosis |
|
|
| Vitreoretinopathy, Neovascular Inflammatory |
|
|
| Poems Syndrome |
|
|
| Adenocarcinoma |
|
|
| Pulmonary Fibrosis |
|
|
| Malignant Pleural Mesothelioma |
|
|
| Papillary Carcinoma |
|
|
| Pancreatic Cancer |
|
|
| Hepatoblastoma |
|
|
| Preretinal Fibrosis |
|
|
| Familial Renal Papillary Carcinoma |
|
|
| Renal Fibrosis |
|
|
| Pancreatic Adenocarcinoma |
|
|
| Acute Kidney Failure |
|
|
| Ischemia |
|
|
| Childhood Hepatocellular Carcinoma |
|
|
| Hereditary Renal Cell Carcinoma |
|
|
| Lung Cancer |
|
|
| Deafness, Autosomal Recessive 97 |
|
|
| Pulmonary Emphysema |
|
|
| Neurofibroma |
|
|
| Glioma |
|
|
| Endometriosis |
|
|
| Pulmonary Edema |
|
|
| Limb Ischemia |
|
|
| Gastric Cancer |
|
|
| Malignant Peripheral Nerve Sheath Tumor |
|
|
| Arthritis |
|
|
| Breast Cancer |
|
|
| Alcoholic Liver Cirrhosis |
|
|
| Colorectal Cancer |
|
|
| Kidney Disease |
|
|
| Spinal Cord Melanoma |
|
|
| Bone Disease |
|
|
| Medulloblastoma |
|
|
| Hepatocellular Carcinoma |
|
|
| Interstitial Lung Disease 2 |
|
|
| Glycogen Storage Disease |
|
|
| Keratoconus |
|
|
| Cholangiocarcinoma |
|
|
| Diffuse Meningeal Melanocytosis |
|
|
| Buerger Disease |
|
|
| Neural Tube Defects |
|
|
| Hepatic Coma |
|
|
| Mesothelioma, Malignant |
|
|
| Sarcoma, Synovial |
|
|
| Myopia |
|
|
| Ovarian Cancer |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Glioblastoma |
|
|
| Prostate Cancer |
|
|
| High Grade Glioma |
|
|
| Pulmonary Hypertension |
|
|
| Gastroesophageal Adenocarcinoma |
|
|
| Myeloma, Multiple |
|
|
| Kidney Cancer |
|
|
| Heart Disease |
|
|
| Endometrial Cancer |
|
|
| Myocardial Infarction |
|
|
| Large Congenital Melanocytic Nevus |
|
|
| Melanoma |
|
|
| Myelodysplastic Syndrome |
|
|
| Polycystic Kidney Disease |
|
|
| Renal Cell Carcinoma, Papillary, 1 |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Chronic Kidney Disease |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Sensorineural Hearing Loss |
|
|
| Systemic Lupus Erythematosus |
|
|
| Crigler-Najjar Syndrome, Type I |
|
|
| Osteoporosis |
|
|
| Diabetes Mellitus |
|
|
| Melanoma, Uveal |
|
|
| Eye Disease |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | HGF | VGNC | VGNC:29834 |
| Mus musculus | HGF | MGD | MGI:96079 |
| Rattus norvegicus | HGF | RGD | RGD:2794 |
| Macaca mulatta | HGF | VGNC | VGNC:73373 |
| Canis familiaris | HGF | VGNC | VGNC:41674 |
| Felis catus | HGF | VGNC | VGNC:67564 |
| Others | HGF | NCBI |