HLA-DMB - major histocompatibility complex, class II, DM beta Gene

Also Known as RING7; D6S221E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3109

About HLA-DMB

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,934,636-32,941,028 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 149 orthologues and 13 paralogues. Broad expression in lymph node (RPKM 104.0), spleen (RPKM 76.5) and 24 other tissues.

Summary

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-DMB Products (1)

mRNA Protein Name
NM_002118.5 NP_002109.2 HLA class II histocompatibility antigen, DM beta chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MHC class II protein complex binding IDA
IDA: Inferred from direct assay
9075930 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21131964 GOA
Biological Process GO Annotation Evidence References Source
involved in MHC class II protein complex assembly IMP
IMP: Inferred from mutant phenotype
8139689 GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
IMP: Inferred from mutant phenotype
8139689 GOA
involved in peptide antigen assembly with MHC class II protein complex IDA
IDA: Inferred from direct assay
7606781 GOA
involved in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
IMP: Inferred from mutant phenotype
8139689 GOA
involved in positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
8139689 GOA
Cellular Component GO Annotation Evidence References Source
part of MHC class II protein complex IDA
IDA: Inferred from direct assay
7606781 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
9075930 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
9075930 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-DMB Protein Structure

C1-set

C1-set: Immunoglobulin C1-set domain (15 - 93)

  • 0
  • 100
  • 141 a.a.
Protein Preferred Names Protein Names

HLA class II histocompatibility antigen, DM beta chain

  • MHC class II HLA-DMB

HLA-DMB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HLA-DMB P28068 AP3M1 Homo sapiens Q9Y2T2
Anti Tag CoIP
33961781
Intra
HLA-DMB P28068 AP3M1 Homo sapiens Q9Y2T2
Anti Tag CoIP
28514442
Intra
HLA-DMB P28068 HLA-DMA Homo sapiens P28067
X-Ray Diffraction
9768757
Cross: Cross-species interaction Intra: Intraspecies interaction

HLA-DMB Antibodies

Cat. No. Product Name Application Reactivity
HY-P86901 HLA DMB Antibody (YA6594) WB, ICC/IF, IF-Tissue, FC Human

Related Diseases

Diseases Alias
Psychologic Dyspareunia

  • Dyspareunia, Psychogenic

  • Non-Organic Dyspareunia
Type 1 Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetes Mellitus Type 1

  • IDDM

  • Type 1 Diabetes

  • Insulin-Dependent Diabetes Mellitus

  • T1D

  • Juvenile-Onset Diabetes

  • Jod

  • Diabetes Mellitus, Type 1

  • Diabetes Mellitus, Insulin-Dependent-1

  • Type I Diabetes Mellitus

  • Autoimmune Diabetes

  • Juvenile Diabetes

  • Juvenile-Onset Diabetes Mellitus

  • Diabetes, Insulin Dependent

  • Insulin-Dependent Diabetes Mellitus-1

  • Diabetes Mellitus Insulin-Dependent

  • Diabetes Autoimmune

  • Diabetes Mellitus, Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 1, Susceptibility To

  • Diabetes Type 1

  • Type I Diabetes

  • Diabetes, Autoimmune

  • T1dm - [Type 1 Diabetes Mellitus]

  • Iddm - [Insulin Dependent Diabetes Mellitus]

  • Type 1 Iddm

  • Juvenile Diabetes Mellitus Without Compications

  • Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

  • Juvenile-Onset Diabetes Mellitus Without Compications

  • Ketosis-Prone Diabetes Mellitus Without Compications

  • Juvenile-Onset-Type Diabetes Mellitus Without Compications
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Severe Combined Immunodeficiency

  • Scid

  • Severe Combined Immunodeficiency Disease

  • Combined T And B Cell Inborn Immunodeficiency

  • Immunodeficiency, Severe Combined

  • Scid - [Severe Combined Immunodeficiencies]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06200 HLA-DMB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HLA-DMB RGD RGD:735096