ZMYM3 - zinc finger MYM-type containing 3 Gene

Also Known as MYM; XFIM; ZNF261; DXS6673E; ZNF198L2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9203

About ZMYM3

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,239,624-71,255,290 (from NCBI)

This gene has 9 transcripts (splice variants), 142 orthologues, 18 paralogues and is associated with 82 phenotypes. Ubiquitous expression in ovary (RPKM 15.3), testis (RPKM 11.9) and 25 other tissues.

Summary

This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked cognitive disability. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2010]

ZMYM3 Products (4)

mRNA Protein Name
NM_001171162.1 NP_001164633.1 zinc finger MYM-type protein 3 isoform 2
NM_001171163.1 NP_001164634.1 zinc finger MYM-type protein 3 isoform 3
NM_005096.3 NP_005087.1 zinc finger MYM-type protein 3 isoform 1
NM_201599.3 NP_963893.1 zinc finger MYM-type protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30021884 GOA
Biological Process GO Annotation Evidence References Source
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in regulation of cell morphogenesis IMP
IMP: Inferred from mutant phenotype
21834987 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IMP
IMP: Inferred from mutant phenotype
36586412 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMYM3 Protein Structure

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (308 - 343)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (346 - 389)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (404 - 440)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (444 - 488)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (490 - 532)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (542 - 578)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (584 - 623)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (629 - 664)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (673 - 710)

zf-FCS

zf-FCS: MYM-type Zinc finger with FCS sequence motif (713 - 751)

DUF3504

DUF3504: Domain of unknown function (DUF3504) (1184 - 1354)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1370 a.a.
Protein Preferred Names Protein Names

zinc finger MYM-type protein 3

  • zinc finger protein 261

ZMYM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZMYM3 Q14202 H2BC21 Homo sapiens Q16778
Crosslink
30021884
Intra
ZMYM3 Q14202 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
ZMYM3 Q14202 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
ZMYM3 Q14202 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
ZMYM3 Q14202 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
ZMYM3 Q14202 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
ZMYM3 Q14202 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
ZMYM3 Q14202 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra
ZMYM3 Q14202 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
ZMYM3 Q14202 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nasal Cavity Adenocarcinoma

  • Adenocarcinoma Of Nasal Cavity

  • Adenocarcinoma Of The Nasal Cavity
Non-Syndromic X-Linked Intellectual Disability

  • X-Linked Non-Syndromic Intellectual Disability

  • Non-Specific X-Linked Mental Retardation

  • X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16090 ZMYM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZMYM3 VGNC VGNC:78886
Bos taurus ZMYM3 VGNC VGNC:37199
Mus musculus ZMYM3 MGD MGI:1927231
Rattus norvegicus ZMYM3 RGD RGD:1564967
Canis familiaris ZMYM3 VGNC VGNC:48647
Felis catus ZMYM3 VGNC VGNC:67259
Others ZMYM3 NCBI