Illudalic acid
Illudalic acid is a sesquiterpenoid natural product discovered in Omphalotus illudens. Illudalic acid inhibits LAR with an IC50 of 2.1 µM, and also inhibits CD45, PTPμ, and SHP2. Illudalic acid derivatives inhibit PTPRD and reduce drug-induced reward behavior in animal models. Illudalic acid can be used in research on LAR-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 18508-77-5
- Formula: C15H16O5
- Molecular Weight:276.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 1.30 µM (LAR phosphatase)[1]
In Vitro
Illudalic acid (IA-30) inhibits LAR with an IC50 of 2.1 µM, and also inhibits CD45 (10 µM), PTPμ (16 µM), and SHP2 (29 µM), whereas its IC50 values against TCPTP, HePTP, PTPε, VHR, and LMWPTP are all >100 µM[3].
Illudalic acid is a pseudo-irreversible LAR inhibitor, KI = 130 µM, kinact = 1.3 min-1[3].
Illudalic acid (20 μM; 10 min) irreversibly inhibits recombinant LAR[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 18508-77-5
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Molecular Weight 276.28
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Formula C15H16O5
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SMILES
CC1(CC2=C(C(C=O)=C3CC(OC(C3=C2C1)=O)O)O)C
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Structure Classification
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Initial Source
Clitocybe illudens
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Uhl GR, et al. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist. Proceedings of the National Academy of Sciences of the United States of America. 2018 Nov 06;115(45):11597-11602. [Content Brief]
[4]. Ling Q, et al. Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorganic & medicinal chemistry. 2008 Aug 01;16(15):7399-409. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Illudalic acid Related Classifications
HY-N12776 Related Classifications
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