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Cat. No.: HY-156032

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PIMPC

PIMPC is a compound with antioxidant and metal-chelating properties. PIMPC is a novel inhibitor of glycogen synthase kinase 3 (GSK-3). PIMPC has potential anti-Alzheimer's disease effect.

For research use only. We do not sell to patients.

CAS No.: 2250244-44-9
Formula: C₂₁H₁₉N₅O
Molecular Weight:357.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PIMPC Chemical Structure

CAS No.: 2250244-44-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PIMPC is a compound with antioxidant and metal-chelating properties. PIMPC is a novel inhibitor of glycogen synthase kinase 3 (GSK-3). PIMPC has potential anti-Alzheimer's disease effect^[1].

All GSK-3 Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
PC-12	IC₅₀	83.18 μM Compound: 9b	Cytotoxicity against rat PC12 cells measured after 24 hrs by MTT assay Cytotoxicity against rat PC12 cells measured after 24 hrs by MTT assay	[PMID: 30772605]
SH-SY5Y	IC₅₀	158.07 μM Compound: 9b	Cytotoxicity against human SH-SY5Y cells measured after 24 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells measured after 24 hrs by MTT assay	[PMID: 30772605]

Chemical Information

CAS No. 2250244-44-9
Molecular Weight 357.41
Formula C₂₁H₁₉N₅O
SMILES

O=C(C1CC1)NC2=NC=CC(/C=N/C3=CC(C4=CC=CC=C4)=CN=C3N)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu D, et al. A quantitative analysis method for a new glycogen synthase kinase-3 inhibitor and its pharmacokinetics in rats. Biomed Chromatogr. 2023 Aug;37(8):e5649. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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