Synstatin (92-119)
Based on 1 publication(s) in Google Scholar
Synstatin (92-119) is an inhibitor of αvβ3/αvβ5 integrins and IGF1R with anti-angiogenic, anti-proliferative, antioxidant and anti-tumor activities. Synstatin (92-119) competitively blocks the capture of αvβ3/αvβ5 integrins and IGF1R by syndecan-1, disrupts the formation of the syndecan-1 : integrin : IGF1R ternary complex, inhibits integrin activation and talin-mediated signaling pathways, and blocks VEGF-induced angiogenesis. Synstatin (92-119) is applicable to research related to cancer and hepatocellular carcinoma.
For research use only. We do not sell to patients.
- Purity: 97.61%
- CAS No.: 1259384-47-8
- Formula: C133H207N35O46
- Molecular Weight:3032.27
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Synstatin (92-119)
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Biological Activity
Synstatin (92-119) directly inhibits the assembly of the Sdc1:αvβ3 integrin:IGF1R ternary complex in a cell-free system[1].
Synstatin (92-119) directly binds to αvβ3 integrin, αvβ5 integrin, and IGF1R on activated vascular endothelial cells[1].
Synstatin (92-119) potently inhibits αvβ3-dependent adhesion and migration of tumor cells in vitro, with an IC50 of 100-300 nM[1].
Synstatin (92-119) (100 nM, 300 nM) potently inhibits VEGF- and αvβ3-dependent angiogenesis in vitro, with an IC50 of 100-300 nM[1].
Synstatin (92-119) inhibits VE-cadherin-induced activation of the Sdc1-coupled IGF1R:αvβ3 integrin complex in vascular endothelial cells in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SSTN92-119 (100 μL of 100 μM in 0.2 mL PBS; subcutaneous; twice per day; 16 weeks) administration for 16 weeks does not induce liver damage or changes in measured biochemical, histopathological, or molecular parameters in healthy rats, with serum AST activity remaining at 116.60 U/L[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, adult, 180-200 g)[2]
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Dosage:100 μL of 100 μM in 0.2 mL PBS
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Administration:subcutaneous; twice per day; 16 weeks
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Result:Showed normal liver histology with no steatosis, necrosis, or neoplastic foci, matching the appearance of untreated control rats.
Maintained serum AST (116.60 U/L), ALT (37.22 U/L), ALP (14.69 U/L), GGT (3.22 U/L), total protein (4.94 g/dl), and albumin (3.31 g/dl) levels comparable to untreated control rats.
Maintained hepatic MDA, NO, SOD, and GSH levels comparable to untreated control rats.
Maintained the percentage of Ki-67-positive and CD105-positive cells comparable to untreated control rats.
Maintained hepatic ITGαVβ3, IGF-1R, VEGF, FGF-2, and AFP protein levels, as well as CD-138, IGF-1R, and VEGF gene expression levels, comparable to untreated control rats.
Chemical Information
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CAS No. 1259384-47-8
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Appearance Solid
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Molecular Weight 3032.27
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Formula C133H207N35O46
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Color White to off-white
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Synonyms
SSTN92-119
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Sequence
Leu-Pro-Ala-Gly-Glu-Lys-Pro-Glu-Glu-Gly-Glu-Pro-Val-Leu-His-Val-Glu-Ala-Glu-Pro-Gly-Phe-Thr-Ala-Arg-Asp-Lys-Glu
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Sequence Shortening
LPAGEKPEEGEPVLHVEAEPGFTARDKE
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (32.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (32.98 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Rapraeger AC, et al. Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis. FEBS J. 2013;280(10):2207-2215. [Content Brief]
[2]. Metwaly HA, et al. Inhibition of the signaling pathway of syndecan-1 by synstatin: A promising anti-integrin inhibitor of angiogenesis and proliferation in HCC in rats. Arch Biochem Biophys. 2018;652:50-58. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 0.3298 mL | 1.6489 mL | 3.2979 mL | 8.2446 mL |
| 5 mM | 0.0660 mL | 0.3298 mL | 0.6596 mL | 1.6489 mL | |
| 10 mM | 0.0330 mL | 0.1649 mL | 0.3298 mL | 0.8245 mL | |
| 15 mM | 0.0220 mL | 0.1099 mL | 0.2199 mL | 0.5496 mL | |
| 20 mM | 0.0165 mL | 0.0824 mL | 0.1649 mL | 0.4122 mL | |
| 25 mM | 0.0132 mL | 0.0660 mL | 0.1319 mL | 0.3298 mL | |
| 30 mM | 0.0110 mL | 0.0550 mL | 0.1099 mL | 0.2748 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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