JNK-IN-11
Based on 1 publication(s) in Google Scholar
JNK-IN-11 (compound 1) is a potent JNK inhibitor with an IC50 value of 2.2, 21.4, 1.8 µM for JNK1, JNK2, JNK3, respectively. JNK-IN-11 has the potential for the research of alzheimer and parkinson disease.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 676594-38-0
- Formula: C12H11NO3S2
- Molecular Weight:281.35
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications Citing Use of MedChemExpress (MCE) JNK-IN-11
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Biological Activity
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JNK1 1.8 μM (IC50) |
JNK3 2.2 μM (IC50) |
JNK2 21.4 μM (IC50) |
JNK-IN-11 (compound 1) exhibits remarkable selectivity over closely related kinases p38a and Erk2. JNK-IN-11 is a Type I ATP-competitive kinase inhibitor where the critical hydrogen bond formed between the inhibitor carbonyl and the NH of Met-149. The thiophene ring of the inhibitor is found to be within hydrophobic contact of the gatekeeper Met-146 side chain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 676594-38-0
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Appearance Solid
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Molecular Weight 281.35
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Formula C12H11NO3S2
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Color White to yellow
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SMILES
O=C(C1=C(NC(CC2=CC=CS2)=O)C=CS1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Biophys Res Commun
Erianin induces ferroptosis in ovarian cancer cells by upregulating PDP2 and activating the JNK signaling pathway. [Abstract]2026 Mar 12:804:153353. PMID: 41619504
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)