JNK-IN-11
Based on 1 publication(s) in Google Scholar
JNK-IN-11 (compound 1) is a potent JNK inhibitor with an IC50 value of 2.2, 21.4, 1.8 µM for JNK1, JNK2, JNK3, respectively. JNK-IN-11 has the potential for the research of alzheimer and parkinson disease.
For research use only. We do not sell to patients.
- Purity : 98.01%
- CAS No.: 676594-38-0
- Formula: C12H11NO3S2
- Molecular Weight:281.35
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) JNK-IN-11
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Biological Activity
Description
IC50 & Target
[1]|
JNK1 1.8 μM (IC50) |
JNK3 2.2 μM (IC50) |
JNK2 21.4 μM (IC50) |
In Vitro
JNK-IN-11 (compound 1) exhibits remarkable selectivity over closely related kinases p38a and Erk2. JNK-IN-11 is a Type I ATP-competitive kinase inhibitor where the critical hydrogen bond formed between the inhibitor carbonyl and the NH of Met-149. The thiophene ring of the inhibitor is found to be within hydrophobic contact of the gatekeeper Met-146 side chain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 676594-38-0
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Appearance Solid
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Molecular Weight 281.35
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Formula C12H11NO3S2
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Color White to yellow
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SMILES
O=C(C1=C(NC(CC2=CC=CS2)=O)C=CS1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Biophys Res Commun
Erianin induces ferroptosis in ovarian cancer cells by upregulating PDP2 and activating the JNK signaling pathway. [Abstract]2026 Mar 12:804:153353. PMID: 41619504
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNK-IN-11 Related Classifications
HY-150053 Related Classifications
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