ERCC1 - ERCC excision repair 1, endonuclease non-catalytic subunit Gene

Also Known as UV20; COFS4; RAD10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2067

About ERCC1

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,407,334-45,451,547 (from NCBI)

This gene has 17 transcripts (splice variants), 184 orthologues and is associated with 4 phenotypes. Ubiquitous expression in skin (RPKM 11.1), ovary (RPKM 9.5) and 25 other tissues.

Summary

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF Endonuclease (also known as ERCC4), and the heterodimeric Endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric Endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

ERCC1 Products (15)

mRNA	Protein	Name
NM_001166049.2	NP_001159521.1	DNA excision repair protein ERCC-1 isoform 3
NM_001369408.1	NP_001356337.1	DNA excision repair protein ERCC-1 isoform 1
NM_001369409.1	NP_001356338.1	DNA excision repair protein ERCC-1 isoform 1
NM_001369410.1	NP_001356339.1	DNA excision repair protein ERCC-1 isoform 4
NM_001369411.1	NP_001356340.1	DNA excision repair protein ERCC-1 isoform 4
NM_001369412.1	NP_001356341.1	DNA excision repair protein ERCC-1 isoform 2
NM_001369413.1	NP_001356342.1	DNA excision repair protein ERCC-1 isoform 2
NM_001369414.1	NP_001356343.1	DNA excision repair protein ERCC-1 isoform 2
NM_001369415.1	NP_001356344.1	DNA excision repair protein ERCC-1 isoform 2
NM_001369416.1	NP_001356345.1	DNA excision repair protein ERCC-1 isoform 2
NM_001369417.1	NP_001356346.1	DNA excision repair protein ERCC-1 isoform 3
NM_001369418.1	NP_001356347.1	DNA excision repair protein ERCC-1 isoform 3
NM_001369419.1	NP_001356348.1	DNA excision repair protein ERCC-1 isoform 3
NM_001983.4	NP_001974.1	DNA excision repair protein ERCC-1 isoform 2
NM_202001.3	NP_973730.1	DNA excision repair protein ERCC-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity	IMP IMP: Inferred from mutant phenotype	14690602	GOA
contributes to DNA binding	IDA IDA: Inferred from direct assay	14734547	GOA
enables damaged DNA binding	IDA IDA: Inferred from direct assay	17720715	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7559382	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	16076955	GOA
contributes to single-stranded DNA endodeoxyribonuclease activity	IDA IDA: Inferred from direct assay	7559382	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA repair	IMP IMP: Inferred from mutant phenotype	25538220	GOA
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	14690602	GOA
involved in mitotic recombination	IMP IMP: Inferred from mutant phenotype	8811092	GOA
involved in negative regulation of protection from non-homologous end joining at telomere	IMP IMP: Inferred from mutant phenotype	14690602	GOA
involved in negative regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	17055345	GOA
acts upstream of or within nucleotide-excision repair	IDA IDA: Inferred from direct assay	3290851	GOA
involved in nucleotide-excision repair	IDA IDA: Inferred from direct assay	22547097	GOA
involved in nucleotide-excision repair	IMP IMP: Inferred from mutant phenotype	7657672	GOA
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	9256505	GOA
involved in telomeric DNA-containing double minutes formation	IMP IMP: Inferred from mutant phenotype	14690602	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ERCC4-ERCC1 complex	IDA IDA: Inferred from direct assay	14690602	GOA
part of ERCC4-ERCC1 complex	IPI IPI: Inferred from physical interaction	16076955	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	14690602	GOA
part of nucleotide-excision repair complex	IDA IDA: Inferred from direct assay	3290851	GOA
part of nucleotide-excision repair factor 1 complex	IDA IDA: Inferred from direct assay	10413517	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERCC1 Protein Structure

Rad10

HHH

0
100
200
297 a.a.

Protein Preferred Names	Protein Names
DNA excision repair protein ERCC-1	excision repair cross-complementation group 1

ERCC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ERCC1	P07992	MKRN3	Homo sapiens	Q6NSB6	Y2H Prey Pooling	25416956
Intra	ERCC1	P07992	TRMT2B	Homo sapiens	Q96GJ1	Y2H Array	25416956
Intra	ERCC1	P07992	TRMT2B	Homo sapiens	Q96GJ1	Y2H Prey Pooling	25416956
Intra	ERCC1	P07992	TRMT2B	Homo sapiens	Q96GJ1	Validated Y2H	25416956
Intra	ERCC1	P07992	MKRN3	Homo sapiens	Q13064	Y2H Array	25416956
Intra	ERCC1	P07992	SLX4	Homo sapiens	Q8IY92	Y2H	19596235
Intra	ERCC1	P07992	SLX4	Homo sapiens	Q8IY92	Confocal	19596235
Intra	ERCC1	P07992	ERCC4	Homo sapiens	Q92889	Anti Bait CoIP	24780295
Intra	ERCC1	P07992	ERCC4	Homo sapiens	Q92889	Pull Down	17289582
Intra	ERCC1	P07992	ERCC4	Homo sapiens	Q92889	Pull Down	16338413
Intra	ERCC1	P07992	ERCC4	Homo sapiens	Q92889	GMS	16338413
Intra	ERCC1	P07992	ERCC4	Homo sapiens	Q92889	Anti Tag CoIP	28514442
Intra	ERCC1	P07992	ERCC4	Homo sapiens	Q92889	NMR	16338413
Intra	ERCC1	P07992	XPA	Homo sapiens	P23025	Anti Tag CoIP	25416956
Intra	ERCC1	P07992	XPA	Homo sapiens	P23025	Y2H	11058119
Intra	ERCC1	P07992	EGFR	Homo sapiens	P00533	Anti Bait CoIP	24780295
Intra	ERCC1	P07992	EGFR	Homo sapiens	P00533	Confocal	24780295
Intra	ERCC1	P07992	EGFR	Homo sapiens	P00533	PLA	24780295
Intra	ERCC1	P07992	UBL7	Homo sapiens	Q96S82	Y2H Array	25416956
Intra	ERCC1	P07992	UBL7	Homo sapiens	Q96S82	Y2H Pooling	16189514
Intra	ERCC1	P07992	VPS37B	Homo sapiens	Q9H9H4	Y2H Array	25416956
Intra	ERCC1	P07992	VPS37B	Homo sapiens	Q9H9H4	Y2H Array	31515488
Intra	ERCC1	P07992	VPS37B	Homo sapiens	Q9H9H4	Y2H Prey Pooling	25416956
Intra	ERCC1	P07992	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
Intra	ERCC1	P07992	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

ERCC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80661	ERCC1 Antibody (YA770)	WB, IHC-P, ICC/IF, IF-Tissue	Human, Mouse
HY-P83997	ERCC1 Antibody (YA3694)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P83997A	ERCC1 Antibody (YA3694)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P85665	ERCC1 Antibody (YA5357)	WB, IHC-P, ICC/IF,	Human
HY-P85792	ERCC1 Antibody (YA5484)	WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Cerebrooculofacioskeletal Syndrome 4	COFS4 Cerebro-Oculo-Facio-Skeletal Syndrome 4 Cofs Syndrome Cerebrooculofacioskeletal Syndrome, Type 4
Cockayne Syndrome B	Cockayne Syndrome Type 2 Cockayne Syndrome, Type B Cockayne Syndrome Type Ii CSB Cockayne Syndrome 2 Cockayne Syndrome Type B Ckn2 Cockayne Syndrome, Type Ii
Cerebrooculofacioskeletal Syndrome 1	Cofs Syndrome COFS1 Pena-Shokeir Syndrome Type 2 Cofs Pena-Shokeir Syndrome, Type Ii Cerebrooculofacioskeletal Syndrome Cerebro-Oculo-Facio-Skeletal Syndrome 1 Pena Shokeir Syndrome Type 2
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Cerebrooculofacioskeletal Syndrome	Cerebro-Oculo-Facio-Skeletal Syndrome Cofs Syndrome Pena-Shokeir Syndrome Type 2 Pena Shokeir Syndrome Type 2
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Xeroderma Pigmentosum, Complementation Group F	Xeroderma Pigmentosum, Group F Xeroderma Pigmentosum Vi Xp6 Xeroderma Pigmentosum, Type F/Cockayne Syndrome XPF Xp, Group F Xeroderma Pigmentosum Group F Xp Group F Xeroderma Pigmentosum, Type 6 Xeroderma Pigmentosum Complementation Group F XP-F Xeroderma Pigmentosum Type F/Cockayne Syndrome XPF/CS
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Xfe Progeroid Syndrome	Xpf-Ercc1 Progeroid Syndrome XFEPS
Xeroderma Pigmentosum, Complementation Group D	Xeroderma Pigmentosum, Group D Xpdc Xeroderma Pigmentosum Iv XPD Xeroderma Pigmentosum Group D Xeroderma Pigmentosum Viii Xp Group D Xp Group H Xp4 Xp8 Xph Xp, Group D Xp4 Xeroderma Pigmentosum Viii, Formerly Xp8, Formerly Xp, Group H, Formerly Xph, Formerly Xeroderma Pigmentosum Complementation Group D XP-D Xp-D/Cs
Xeroderma Pigmentosum, Complementation Group A	Xeroderma Pigmentosum Group A Xp1 Xeroderma Pigmentosum, Group A XPA Xeroderma Pigmentosum I Xeroderma Pigmentosum Complementation Group A Xp Group A Xp, Group A Xeroderma Pigmentosum 1 Xeroderma Pigmentosum, Type 1 XP-A
Xeroderma Pigmentosum, Complementation Group G	Xeroderma Pigmentosum, Group G Xeroderma Pigmentosum Vii Xp7 XPG Xeroderma Pigmentosum Group G Xp Group G Xp, Group G Xpgc Xeroderma Pigmentosum, Group G/Cockayne Syndrome Xeroderma Pigmentosum, Type 7 Xeroderma Pigmentosum Complementation Group G XP-G Xp-G/Cs Xeroderma Pigmentosum Group G/Cockayne Syndrome
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Xeroderma Pigmentosum, Complementation Group B	Xeroderma Pigmentosum Group B Xeroderma Pigmentosum, Group B XPB Xpbc Xp Group B Xp, Group B Xeroderma Pigmentosum Complementation Group B XP-B Xeroderma Pigmentosum Group B With Cockayne Syndrome Xeroderma Pigmentosum Ii Xp2 Xp-B/Cs
Cheilitis
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Xeroderma Pigmentosum, Complementation Group C	Xeroderma Pigmentosum, Group C XPC Xpcc Xeroderma Pigmentosum Iii Xp3 Xeroderma Pigmentosum Group C Xp Group C Xp, Group C Xeroderma Pigmentosum, Type 3 Xeroderma Pigmentosum Complementation Group C XP-C
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Cockayne Syndrome A	Cockayne Syndrome Type 1 Cockayne Syndrome, Type A Cockayne Syndrome Type I CSA Cockayne Syndrome Classic Form Cockayne Syndrome Classical Cockayne Syndrome Type A Ckn1
Uv-Sensitive Syndrome	Uvss Uv Sensitive Syndrome Ultraviolet Sensitive Syndrome
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Vallecula Cancer	Malignant Tumor Of Vallecula
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Testicular Disease	Testicular Dysfunction Testicular Diseases Disorder Of Testis Testis Disorder Testicular Disorders
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100690	NSC16168	Inhibitor	98.11%	Unkown
HY-147356	ERCC1-XPF-IN-2	Inhibitor	98.54%	Unkown
HY-143498	ERCC1-XPF-IN-1	Inhibitor	99.37%	Unkown
HY-RS04478	ERCC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-161623	ERCC1/XPA interaction inhibitor 1	Inhibitor	/	Unkown
HY-RS18274	Ercc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24752	Ercc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ERCC1	VGNC	VGNC:28568
Felis catus	ERCC1	VGNC	VGNC:61930
Rattus norvegicus	ERCC1	RGD	RGD:1306992
Canis familiaris	ERCC1	VGNC	VGNC:40441
Mus musculus	ERCC1	MGD	MGI:95412
Macaca mulatta	ERCC1	VGNC	VGNC:72422
Others	ERCC1	NCBI