MYBL1 - MYB proto-oncogene like 1 Gene

Also Known as AMYB; A-MYB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4603

About MYBL1

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:66,562,175-66,613,218 (from NCBI)

This gene has 6 transcripts (splice variants), 222 orthologues and 6 paralogues. Broad expression in lymph node (RPKM 9.0), testis (RPKM 6.1) and 15 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MYBL1 Products (3)

mRNA Protein Name
NM_001080416.4 NP_001073885.1 myb-related protein A isoform 1
NM_001144755.3 NP_001138227.1 myb-related protein A isoform 2
NM_001294282.2 NP_001281211.1 myb-related protein A isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
7987850 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7987850 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7987850 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYBL1 Protein Structure

Myb_DNA-bind_6

Myb_DNA-bind_6: Myb-like DNA-binding domain (38 - 98)

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (139 - 183)

LMSTEN

LMSTEN: LMSTEN motif (239 - 286)

Cmyb_C

Cmyb_C: C-myb, C-terminal (486 - 649)

  • 0
  • 200
  • 400
  • 600
  • 752 a.a.
Protein Preferred Names Protein Names

myb-related protein A

  • myb-like protein 1

Related Diseases

Diseases Alias
Adenoid Cystic Carcinoma

  • Adenocystic Carcinoma

  • Cribriform Carcinoma

  • Cylindroma

  • Carcinoma Adenoid Cystic

  • Carcinoma, Adenoid Cystic

  • Adenoid Cystic Carcinoma Of Salivary Gland

  • Eccrine Dermal Cylindroma

  • Carcinoma, Cribriform
Thalamic Neoplasm

  • Malignant Neoplasm Of Thalamus

  • Malignant Tumor Of Thalamus

  • Tumor Of Thalamus
Bartholin'S Gland Adenoid Cystic Carcinoma

  • Bartholin Gland Adenoid Cystic Carcinoma
Breast Adenoid Cystic Carcinoma

  • Adenoid Cystic Breast Carcinoma

  • Adenoid Cystic Carcinoma Of Breast

  • Mammary Adenocystic Carcinoma
Dysembryoplastic Neuroepithelial Tumor

  • Dysembryoplastic Neuroepithelial Tumour

  • Dysembryoplastic Neuroepithelial Neoplasm

  • Dnet
Tonsil Cancer

  • Tonsillar Neoplasms

  • Malignant Neoplasm Of Faucial Tonsil

  • Malignant Neoplasm Of Palatine Tonsil

  • Malignant Neoplasm Of Tonsil, Faucial

  • Malignant Tonsillar Tumor

  • Malignant Tumor Of Tonsil

  • Tonsillar Carcinoma

  • Malignant Neoplasm Tonsil
Eccrine Papillary Adenocarcinoma

  • Digital Papillary Adenocarcinoma

  • Sweat Gland Adenocarcinoma

  • Digital Papillary Eccrine Carcinoma Of Skin
Cutaneous Adenocystic Carcinoma

  • Adenoid Cystic Eccrine Carcinoma

  • Adenoid Cystic Carcinoma Of The Skin

  • Adenoid Cystic Eccrine Carcinoma Of Skin
Diffuse Astrocytoma

  • Diffuse Astrocytoma, Low Grade

  • Who Grade Ii Astrocytoma

  • Fibrillary Astrocytoma

  • Gemistocytic Astrocytoma

  • Low-Grade Diffuse Astrocytoma

  • Protoplasmic Astrocytoma
Salivary Gland Carcinoma

  • Salivary Gland Cancer

  • Malignant Neoplasm Of Salivary Gland

  • Salivary Gland Neoplasms
Chordoid Glioma

  • Chordoid Glioma Of The Third Ventricle
Oropharynx Cancer

  • Oropharyngeal Cancer

  • Oropharyngeal Carcinoma

  • Malignant Neoplasm Of Oropharynx

  • Malignant Oropharyngeal Tumor

  • Malignant Tumor Of Oropharynx

  • Malignant Tumour Of Mesopharynx

  • Oropharyngeal Cancer, Adult

  • Cancer Of The Oropharynx
Lung Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma Of Lung

  • Pulmonary Adenoid Cystic Carcinoma
Eccrine Adenocarcinoma
Pleomorphic Xanthoastrocytoma

  • Pxa

  • Pleomorphic Xantho-Astrocytoma
Ceruminoma

  • Ceruminous Adenoma

  • External Auditory Canal Ceruminous Adenoma
Salivary Gland Adenoid Cystic Carcinoma

  • Cylindroma
Cerebellar Liponeurocytoma

  • Lipomatous Medulloblastoma

  • Central Neurocytoma
Breast Mucoepidermoid Carcinoma

  • Mucoepidermoid Carcinoma Of Breast

  • Mucoepidermoid Carcinoma Of The Breast
Ceruminous Adenocarcinoma
Pilomyxoid Astrocytoma
Childhood Oligodendroglioma

  • Pediatric Oligodendroglioma

  • Oligodendroglioma, Childhood
Astroblastoma

  • Cerebral Astroblastoma
Pleomorphic Adenoma Carcinoma

  • Carcinoma Ex Pleomorphic Adenoma

  • Carcinoma In Pleomorphic Adenoma
Solitary Fibrous Tumor/Hemangiopericytoma

  • Sft/Hpc
Cerebellum Cancer

  • Cerebellar Neoplasms

  • Cerebellar Cancer

  • Malignant Tumor Of Cerebellum

  • Malignant Neoplasm Of Cerebellum
Subependymal Glioma

  • Mixed Subependymoma-Ependymoma

  • Subependymal Astrocytoma

  • Who Grade I Ependymal Tumor

  • Glioma, Subependymal
Acute Basophilic Leukemia
Low Grade Glioma

  • Benign Glioma
Burkitt Lymphoma

  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma
Pilocytic Astrocytoma

  • Juvenile Pilocytic Astrocytoma

  • Grade I Astrocytic Tumor

  • Piloid Astrocytoma
Central Nervous System Benign Neoplasm

  • Benign Neoplasm Of The Central Nervous System
Salivary Gland Disease

  • Salivary Gland Disorders

  • Salivary Gland Diseases

  • Non-Neoplastic Salivary Gland Disease

  • Non-Neoplastic Salivary Gland Disorder

  • Disorder Of Salivary Gland

  • Lesion Of Salivary Gland Nos
Spinal Cord Disease

  • Spinal Cord Diseases

  • Myelopathy

  • Bone Marrow Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08871 MYBL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21658 Mybl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28176 Mybl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MYBL1 VGNC VGNC:68371
Macaca mulatta MYBL1 VGNC VGNC:75091
Rattus norvegicus MYBL1 RGD RGD:1306940
Canis familiaris MYBL1 VGNC VGNC:43520
Bos taurus MYBL1 VGNC VGNC:31778
Mus musculus MYBL1 MGD MGI:99925
Others MYBL1 NCBI