OSMR - oncostatin M receptor Gene

Also Known as OSMRB; PLCA1; IL-31RB; OSMRbeta; IL-31R-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9180

About OSMR

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:38,846,012-38,945,579 (from NCBI)

This gene has 5 transcripts (splice variants), 531 orthologues, 23 paralogues and is associated with 2 phenotypes. Ubiquitous expression in gall bladder (RPKM 13.2), placenta (RPKM 11.5) and 24 other tissues.

Summary

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

OSMR Products (6)

mRNA Protein Name
NM_001168355.3 NP_001161827.1 oncostatin-M-specific receptor subunit beta isoform 2 precursor
NM_001323504.2 NP_001310433.1 oncostatin-M-specific receptor subunit beta isoform 2 precursor
NM_001323505.2 NP_001310434.1 oncostatin-M-specific receptor subunit beta isoform 1 precursor
NM_001323506.2 NP_001310435.1 oncostatin-M-specific receptor subunit beta isoform 3 precursor
NM_001323507.2 NP_001310436.1 oncostatin-M-specific receptor subunit beta isoform 4 precursor
NM_003999.3 NP_003990.1 oncostatin-M-specific receptor subunit beta isoform 1 precursor

OSMR Protein Structure

fn3

fn3: Fibronectin type III domain (539 - 607)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 979 a.a.
Protein Preferred Names Protein Names

oncostatin-M-specific receptor subunit beta

  • IL-31 receptor subunit beta

OSMR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OSMR Q99650 NDUFS1 Homo sapiens P28331
Anti Bait CoIP
32807793
Intra
OSMR Q99650 NDUFS1 Homo sapiens P28331
PLA
32807793
Intra
OSMR Q99650 LHX2 Homo sapiens P50458
Y2H Array
32296183
Intra
OSMR Q99650 LHX2 Homo sapiens P50458
Y2H Prey Pooling
32296183
Intra
OSMR Q99650 NDUFS2 Homo sapiens O75306
PLA
32807793
Intra
OSMR Q99650 NDUFS2 Homo sapiens O75306
Anti Bait CoIP
32807793
Intra
OSMR Q99650 GPRC5D Homo sapiens Q9NZD1
Y2H Array
32296183
Intra
OSMR Q99650 GPRC5D Homo sapiens Q9NZD1
Y2H Prey Pooling
32296183
Intra
OSMR Q99650 GPRC5D Homo sapiens Q9NZD1
Validated Y2H
32296183
Intra
OSMR Q99650 JAK1 Homo sapiens P23458
Anti Tag CoIP
33961781
Intra
OSMR Q99650 JAK1 Homo sapiens P23458
Anti Tag CoIP
28514442
Intra
OSMR Q99650 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
OSMR Q99650 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
OSMR Q99650 HSPA9 Homo sapiens P38646
Anti Bait CoIP
32807793
Intra
OSMR Q99650 HSPA9 Homo sapiens P38646
PLA
32807793
Intra
OSMR Q99650 ATP5IF1 Homo sapiens Q9UII2
PLA
32807793
Intra
OSMR Q99650 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
OSMR Q99650 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
OSMR Q99650 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
OSMR Q99650 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
OSMR Q99650 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OSMR Proteins

Cat. No. Product Name Accession Purity
HY-P72500 OSMR beta Protein, Human (HEK293, His) Q99650 (E28-S739) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Amyloidosis, Primary Localized Cutaneous, 1

  • PLCA1

  • Pca

  • Amyloidosis Ix

  • Familial Lichen Amyloidosis

  • Amyloidosis, Primary Cutaneous, 1

  • Pca1

  • Lichen Amyloidosis, Familial

  • Amyloidosis, Familial Cutaneous Lichen

  • Primary Localized Cutaneous Amyloidosis 1

  • Familial Primary Localized Cutaneous Amyloidosis-1

  • Amyloidosis Type 9

  • Plca

  • Primary Cutaneous Amyloidosis

  • Primary Localized Cutaneous Amyloidosis

  • Amyloidosis, Primary Cutaneous
Primary Cutaneous Amyloidosis

  • Plca

  • Primary Localized Cutaneous Amyloidosis

  • Familial Primary Localized Cutaneous Amyloidosis

  • Amyloidosis Ix

  • Lichen Amyloidosis Familial

  • Amyloidosis, Primary Cutaneous

  • Pca

  • Amyloidosis 9

  • Amyloidosis Familial Cutaneous Lichen

  • Fplca

  • Familial Lichen Amyloidosis
Amyloidosis

  • Amyloid Disease

  • Amyloid

  • Amyloid Degeneration

  • Amyloidosis Nos

  • Amyloid Deposition

  • Amyloid Infiltration

  • Idiopathic Amyloidosis

  • Hyaloid Degeneration

  • Lardaceous Degeneration
Lichen Amyloidosis

  • Amyloid Lichen

  • Lichen Amyloidosus

  • Amyloidosis, Primary Cutaneous
Macular Amyloidosis

  • Amyloidosis, Macular
Amyloidosis, Primary Localized Cutaneous, 3

  • Amyloidosis Cutis Dyschromica

  • PLCA3

  • Acd

  • Primary Localized Cutaneous Amyloidosis 3

  • Amyloidosis Cutis Dyschromia
Allergic Urticaria
Bone Cancer

  • Malignant Bone Neoplasm

  • Bone Carcinoma

  • Bone Neoplasms

  • Bone Neoplasm

  • Bone Tumour

  • Ca - Bone Cancer

  • Malignant Bone Tumour

  • Malignant Neoplasm Of Bone

  • Malignant Osseous Tumor

  • Neoplasm Of Bone

  • Osseous Tumor

  • Osteosarcoma Of Bone

  • Osteogenic Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09851 OSMR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17541 Osmr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23999 Osmr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris OSMR VGNC VGNC:44167
Mus musculus OSMR MGD MGI:1330819
Bos taurus OSMR VGNC VGNC:32475
Felis catus OSMR VGNC VGNC:68659
Rattus norvegicus OSMR RGD RGD:1302983
Macaca mulatta OSMR VGNC VGNC:75721
Others OSMR NCBI